Use of TOF-SIMS to study adsorption and loading behavior of methylene blue and papain in a nano-porous silicon layer.

Journal of the American Society for Mass Spectrometry
Ivan M KempsonC A Prestidge

Abstract

TOF-SIMS was applied to study the cross-sectional distribution of methylene blue and papain in porous silicon layers. Elemental and molecular information were used to study their distributions in the porous region and the chemistry of their adsorption. Methylene blue (MW = 284 Da) penetrated to the base to the pores. Positive ions (SiCH(3)(+)) suggest methylene blue binds to the substrate via its methyl groups. Negative fragments (SiOSH(3)(-) and SiO(2)SCH(-)) also suggested chemisorption via O bridging of the substrate Si and methylene blue S. The larger Papain molecule (23,406 Da) distributed itself in a similar manner to methylene blue demonstrating larger molecules can be effectively incorporated into such pore structures.

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Citations

Oct 22, 2013·Environmental Toxicology and Pharmacology·Marcin MikulewiczHenryk Górecki
Mar 10, 2016·Colloids and Surfaces. B, Biointerfaces·Paul JoyceClive A Prestidge
Sep 5, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Paul JoyceClive A Prestidge
Nov 28, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Ivan M KempsonClive A Prestidge
Apr 7, 2011·Chemical Society Reviews·Ivan M Kempson, Enzo Lombi
Jan 6, 2019·Materials·Chloé RodriguezMiguel Manso Silván
Jun 10, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Ivan M KempsonTimothy J Barnes

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