Use of topical povidone-iodine resulting in an iododerma-like eruption

The Journal of Dermatology
Maureen MasséLinda Hua Zhou

Abstract

Iododerma is a rare skin eruption that is usually induced by the systemic use of iodide-containing radiographic contrast medium or treatment with oral potassium iodide therapy. Iododerma has also rarely been reported to occur following topical application of iodine. We herein report the case of a 42-year-old male who developed multiple pinpoint pustules on both lower extremities. Three days after the eruption began, the patient started applying topical 10% povidone-iodine solution to the lesions. During this treatment, the lesions enlarged into multiple 2-9-cm pus-filled bullae, limited to the treated areas. Lesional bacterial culture swab and Gram stain were negative. Blood cultures were also negative and the patient's white blood cell count was normal. A punch biopsy specimen revealed pseudoepitheliomatous hyperplasia and dermal-epidermal separation with epidermal necrosis and underlying abscess formation. A superficial and deep perivascular, interstitial and perifollicular infiltrate containing numerous neutrophils, with abscess formation and eosinophils was also seen. This histology was consistent with iododerma and the patient's lesions involuted following cessation of topical iodine use, leaving only post-inflammatory hyp...Continue Reading

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Citations

Dec 18, 2010·Thyroid : Official Journal of the American Thyroid Association·Arthur F GuerreroK M Mohamed Shakir
Apr 9, 2013·Cutaneous and Ocular Toxicology·Cihangir AliagaogluErtugrul Kaya
Jan 30, 2014·The British Journal of Dermatology·A L Young, M E Grossman
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Feb 9, 2019·Journal of Cutaneous Pathology·Angela WipfDaniel Miller
Oct 14, 2011·The American Journal of Dermatopathology·Jinane El-KhouryOssama Abbas
May 20, 2015·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Kathryn EcholsAvis Yount
Feb 16, 2020·International Journal of Dermatology·Noureddine LitaiemFaten Zeglaoui
Jun 15, 2011·American Journal of Clinical Dermatology·Aurélie Du-ThanhBernard Guillot

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