Use of topical therapies for pediatric psoriasis: A systematic review

Pediatric Dermatology
Georgios Kravvas, Karolina Gholam

Abstract

Psoriasis is one of the most common chronic skin diseases, affecting 1%-3% of the general population. It can have a significant negative impact on a patient's quality of life, and in approximately 30% of patients first symptoms can be traced back to childhood. We have performed a comprehensive literature search using the MEDLINE database in order to ascertain the efficacy and adverse reactions of topical treatments in pediatric psoriasis. A total of 13 relevant articles were identified on the following topical agents: corticosteroids, calcineurin inhibitors, vitamin D analogs, and dithranol. Corticosteroids achieved clearance in 72.7% of patients. Calcitriol lead to a 57.2%-100% mean improvement in severity, and calcipotriol to 52%-64%. Combination of calcipotriol and corticosteroids achieved an improvement in mean severity ranging between 32.1% and 80%. Treatment with tacrolimus lead to an >50% improvement. Finally, short contact dithranol lead to a variable response in clearance between different studies, ranging between 3.7% and 81%. No serious adverse reactions were documented, the most common local reaction being irritation. Pediatric psoriasis is a common and challenging condition with no easy and definitive solution. Top...Continue Reading

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Citations

Nov 28, 2018·Journal of Biomedical Materials Research. Part a·Fei XuHong Zheng
Sep 4, 2019·Journal of Cutaneous Medicine and Surgery·Lyn GuentherYves Poulin
Feb 16, 2020·Drug Delivery and Translational Research·Juliana Santos Rosa ViegasMaria Vitória Lopes Badra Bentley
Jan 3, 2021·Pediatrics in Review·Joana MatosManuela Selores
Aug 20, 2019·The Journal of Investigative Dermatology·Haoming LiuAmy S Paller
Apr 1, 2021·Expert Review of Clinical Pharmacology·Emmanuel MahéCéline Phan

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