Use of transgenic mice in lipoprotein metabolism and atherosclerosis research

Prostaglandins, Leukotrienes, and Essential Fatty Acids
Louis M HavekesM H Hofker

Abstract

In APOE*3-Leiden transgenic mice the atherosclerotic lesion size is correlated with plasma cholesterol. In these mice the plasma lipid levels are positively correlated with the relative amount of APOE 3-Leiden protein on the VLDL particle. The plasma cholesterol levels are influenced by diet, age and gender, mainly due to an effect of these factors on VLDL production rate. Excess of APOC1 protein does inhibit the hepatic clearance of VLDL remnant particles, whereas excess of apoE leads to a hampered extra-hepatic lipolysis of VLDL triglyceride.

Citations

May 29, 2013·The Proceedings of the Nutrition Society·Henk F J Hendriks
Mar 20, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·P Padmini S J KhedoePieter S Hiemstra

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