PMID: 2497683Jan 1, 1989Paper

Use of TRH analogues in motorneurone disease

Annals of the New York Academy of Sciences
R J Guiloff

Abstract

TRH analogues have a longer half-life than does TRH and enhanced neuropharmacological actions. In motorneurone disease (MND), no benefit was reported with MK771 and DN1417. Focal, transient, and slight improvements in weakness and spasticity were described with CG3509. A controlled trial with a single intravenous dose of RX 77368 showed improvements in dysarthria, tongue movements, respiration, swallowing, and spasticity lasting up to 72 hours. Changes in muscle force were of no functional significance. There was an acute 25-30% increase in mean corrected fiber density and in mean macro-EMG parameters in biceps, but no change in amplitude or area of single macro-EMG motor units followed during the 2-hour infusions. An acute, direct or indirect, central effect of RX77368 on recruitment order or on activation threshold of pathological motor units is suggested. In a subacute open trial with repeated intravenous infusions of RX77368 (median 2 weeks), improvement in bulbar function in 8 of 12 responders, cramps (5 of 9), and spasticity (5 of 8) were maintained for medians of 18, 14, and 7 days, respectively. Side effects were prominent with doses above 0.2 mg/kg. Disease progression has not been halted with any analogue, but whether...Continue Reading

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Citations

May 3, 1990·European Journal of Pharmacology·S VonhofV M Labroo
Jan 30, 2002·Pediatric Neurology·Michael J Kubek, Bhuwan P Garg
Jul 16, 1994·BMJ : British Medical Journal·R W OrrellR J Guiloff
Nov 1, 1990·Journal of Neurology, Neurosurgery, and Psychiatry·H Modarres-Sadeghi, R J Guiloff
Feb 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·A Goonetilleke, R J Guiloff
Jan 1, 1991·Mayo Clinic Proceedings·D B Williams, A J Windebank
Dec 27, 1994·European Journal of Pharmacology·S B Deshpande, J E Warnick
Apr 20, 2012·The Cochrane Database of Systematic Reviews·Renske I WadmanAlexander F J E Vrancken

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