PMID: 8938346Feb 1, 1996Paper

Use of tubularized peritoneal free grafts as urethral substitutes in the rabbit

Journal of Pediatric Surgery
D B ShaulB E Hardy

Abstract

As an alternative to bladder mucosa, free grafts of tubularized peritoneum were used as urethral substitutes in a rabbit model of hypospadias. In group 1, six mature rabbits underwent partial penile urethrectomy followed by interposition of a 2-cm-long peritoneal-lined tube graft. These animals had urethrograms performed at 3 months and were killed at 6 (n = 4) or 12 (n = 2) months. In group 2, six rabbits underwent total penile urethrectomy with placement of 3-cm-long grafts. These animals were killed 1 to 4 weeks after surgery. Clinical assessment and gross examination of the 12 rabbits showed no urinary retention, two small fistulas at the proximal anastomosis, and no strictures or diverticular. At 6 and 12 months (group 1) the urethra had healed completely and the graft edges were not visible. In group 2, 1 to 4 weeks after surgery the graft was intact and the interface between the graft and native urethra was visible. Histological studies of the grafts were compared with control peritoneum. At 1 week, a high-density single-cell layer was present. Beginning at 2 weeks, a multilayered epithelium was present, which became more organized in the older grafts. Neovascularity became visible in the subepithelial layer at 2 weeks. ...Continue Reading

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Citations

Feb 15, 2001·The Journal of Urology·L NanniL Perrelli
Jan 12, 2012·TheScientificWorldJournal·Manish N Patel, Anthony Atala
Oct 31, 2007·Asian Journal of Andrology·Cagri SadeLutfu Bas
Nov 4, 2005·Veterinary Surgery : VS·Gultekin AtalanIsa Ozaydin
Apr 3, 2004·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R C LaraS Arap
Jul 8, 2008·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Geovanne F SouzaAntonio Macedo
Aug 24, 1999·The Journal of Urology·D B Joseph, L M Pérez
Feb 23, 2021·Journal of Tissue Engineering·Biao ChenShengwen Li

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