PMID: 9174984Mar 1, 1997Paper

Use of type I and type IV hypersensitivity responses to define the immunopharmacological profile of drugs

Journal of Pharmacological and Toxicological Methods
F Di PierroF Leoni

Abstract

Administration of antigen suspended in incomplete Freund's adjuvant supplemented with either heat-killed Mycobacterium tuberculosis (complete Freund's adjuvant, CFA) or Bordetella pertussis toxin sensitizes animals so that subsequent antigen challenge leads to delayed-type (DTH) or immediate type hypersensitivity (ITH) responses, named type IV and type I, respectively. Appropriate timing of administration of drugs with respect to immunization or antigen challenge allowed to detect predominantly immunosuppressive, antiinflammatory or antianaphylactic activities. Among the reference drugs tested, only cyclosporin A (CsA) and dexamethasone (Dex) markedly inhibited DTH reaction, due to their immunosuppressive and antiinflammatory activities, respectively, whereas leflunomide and indomethacin resulted less potent. On the other hand, only dexchlorpheniramine, a histamine-receptor antagonist, afforded significant protection against anaphylactic shock, a form of ITH. Two new chemical entities were studied according to this protocol: ITF 1697, a chemically stabilized C-reactive protein-derived tetrapeptide, and ITF 2018, a leflunomide analogue. Data obtained with these new compounds showed that ITF 1697 has antianaphylactic activity, wh...Continue Reading

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Citations

May 2, 2003·Archives of Pharmacal Research·Taek Hyeon KimHyun Chul Lee
Dec 18, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Elizabeth KudlaczPaul Changelian
Dec 3, 2010·The Journal of Small Animal Practice·D Lanore, D Sayag
Sep 1, 2007·Journal of Toxicology and Environmental Health. Part a·Len TurczynowiczAngela McLean
Mar 6, 2009·International Journal of Phytoremediation·Stephen D EbbsAlan J M Baker
Jul 25, 2000·Archives of Environmental Health·S E RodenbeckA Rene

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