Use of ursodeoxycholic acids in a dog with chronic hepatitis: effects on serum hepatic tests and endogenous bile acid composition

Journal of Veterinary Internal Medicine
D J MeyerD F Senior

Abstract

A dog with severe cholestasis secondary to chronic hepatitis was treated with ursodeoxycholic acid (UDCA) PO. After 2 weeks of daily treatment, the dog was more active and had an improved appetite. Monthly serum biochemical determinations and analysis of individual bile acid profiles documented improvement in hepatobiliary tests and a marked reduction in the concentrations of potentially hepatotoxic endogenous bile acids. These effects were maintained for approximately 6 months. The findings in this dog are similar to those reported for human patients treated with UDCA and provide preliminary evidence in support of its continued evaluation in the treatment of cholestatic liver disease in the dog.

References

Aug 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M YoshikawaS Ishizaka
Mar 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Z R VlahcevicP B Hylemon
Nov 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M BertolottiN Carulli
Nov 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P MarteauR Poupon
Nov 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D L SchmuckerK Kitani
Jan 1, 1989·Veterinary Pathology·M B ThompsonP C Blair
Jul 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S HillaireR Poupon
Sep 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B CombesG Garcia-Tsao
Jan 1, 1994·Scandinavian Journal of Gastroenterology. Supplement·A F Hofmann
Jan 1, 1994·Scandinavian Journal of Gastroenterology. Supplement·K Einarsson
Dec 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S KrähenbühlJ Reichen
Apr 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R E PouponR Poupon
Jun 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G RudolphA Stiehl

❮ Previous
Next ❯

Citations

Jan 24, 2004·Clinical Techniques in Small Animal Practice·Adam Honeckman
Jul 31, 2013·The Veterinary Clinics of North America. Small Animal Practice·Jean-Michel VandeweerdPascal Gustin
Mar 23, 2004·The Veterinary Clinics of North America. Small Animal Practice·Sharon A Center
Mar 8, 2003·The Journal of Small Animal Practice·Y L McGrottyC M Knottenbelt
Mar 24, 2009·Regulatory Toxicology and Pharmacology : RTP·Julie I PapayChristine M Hunt
Apr 20, 2004·Australian Veterinary Journal·L A AbrahamS A Holloway
Mar 8, 2019·Journal of Veterinary Internal Medicine·Cynthia R L WebsterPenny J Watson
Oct 7, 2000·Journal of Dental Research·R P HarperL L Bellinger
Dec 2, 2017·Journal of Veterinary Internal Medicine·V M Eulenberg, J A Lidbury
May 7, 2021·Veterinary Medicine and Science·Fausto QuintavallaRoberto Ramoni
Oct 30, 2021·Journal of Veterinary Internal Medicine·Frederik AllanKatie E McCallum

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.