Use of vaginally administered chlorhexidine during labor to improve pregnancy outcomes.

Obstetrics and Gynecology
R L GoldenbergSten H Vermund

Abstract

Our objective was to determine the potential for chlorhexidine used as a vaginal and neonatal wash to reduce adverse outcomes of pregnancy, especially in developing countries. We searched the English literature from January 1950 through October 2005 for all articles related to the use of chlorhexidine. Every article on chlorhexidine use in pregnancy and in the newborn period was reviewed in detail. The results of every study in which chlorhexidine was used as a vaginal treatment, with or without a neonatal wash, for all pregnancy outcomes except mother-to-child transmission of human immunodeficiency virus, are summarized in this review. Chlorhexidine is a highly effective killer of most bacteria, has an excellent safety profile, rarely is associated with bacterial resistance, is easy to administer, and costs a few cents per application. When used as a vaginal or newborn disinfectant, it clearly reduces bacterial load, including transmission of Group B Streptococcus from the mother to the fetus. Nevertheless, in developed countries, chlorhexidine generally has not been shown to significantly reduce life-threatening maternal or neonatal infections. However, 2 large but not randomized studies, one in Malawi and the other in Egypt,...Continue Reading

References

Jun 1, 1976·Journal of Periodontal Research·C R SchiottH Löe
Jun 1, 1976·Journal of Periodontal Research·I C MackenzieC R Schiött
May 1, 1977·Scandinavian Journal of Dental Research·C G Emilson
Dec 1, 1977·Journal of Clinical Periodontology·D E Case
Jun 1, 1977·The Journal of Pediatrics·R L NaeyeC Marboe
Sep 1, 1975·Scandinavian Journal of Dental Research·J R JohansenH M Eriksen
Jan 1, 1992·Gynecologic and Obstetric Investigation·M ShubairB Larsen
Apr 1, 1989·European Journal of Obstetrics, Gynecology, and Reproductive Biology·L A KolléeR G Wintermans
Feb 1, 1988·Contact Dermatitis·A Bergqvist-Karlsson
Jun 1, 1986·Journal of Periodontology·G GreensteinR Jaffin
Apr 1, 1985·European Journal of Obstetrics, Gynecology, and Reproductive Biology·K K ChristensenG Kahlmeter
Jan 1, 1973·Journal of Periodontal Research. Supplement·D M Foulkes
Jan 1, 1973·Journal of Periodontal Research. Supplement·T S Hennessey
Nov 1, 1983·European Journal of Obstetrics, Gynecology, and Reproductive Biology·K K ChristensenV Lindén
May 1, 1984·The Journal of Infection·H VorherrR H Messer
Aug 1, 1995·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A H AdriaanseT K Eskes
May 1, 1994·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·M A al-Tannir, H S Goodman
Feb 1, 1995·Acta Obstetricia Et Gynecologica Scandinavica·Y HennequinA Vokaer
Jan 1, 1993·Gynecologic and Obstetric Investigation·P AxemoS Bergström
Dec 1, 1995·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S R MoyoA Ljungh
Feb 1, 1997·American Journal of Obstetrics and Gynecology·K M SweetenJ D Blanco
Aug 1, 1996·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S R MoyoA Ljungh
Aug 26, 1999·International Journal of Antimicrobial Agents·B Stray-PedersenM Vangdal
Dec 29, 2000·Acta Obstetricia Et Gynecologica Scandinavica·L MaleckieneS Bergstrom
Feb 15, 2001·JAMA : the Journal of the American Medical Association·R L Goldenberg, A H Jobe
Mar 6, 2002·Seminars in Perinatology·Ronald S Gibbs
Oct 12, 2002·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·F FacchinettiA Volpe
Jul 16, 2003·American Journal of Obstetrics and Gynecology·Dwight J RouseJohn C Hauth
Jan 1, 1958·Antonie van Leeuwenhoek·H BEEUWKES
Oct 4, 2003·American Journal of Obstetrics and Gynecology·Robert L Goldenberg, Cortney Thompson
Jan 15, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Craig M WilsonJames McIntyre
Feb 13, 2004·Journal of Pediatric Endocrinology & Metabolism : JPEM·Ouyporn PanamontaPagakrong Lumbiganon

❮ Previous
Next ❯

Citations

Jul 6, 2013·Australian Critical Care : Official Journal of the Confederation of Australian Critical Care Nurses·Elsa AfonsoElisabeth Gallart
Sep 3, 2013·Best Practice & Research. Clinical Obstetrics & Gynaecology·N Arulkumaran, M Singer
Jul 29, 2006·The Pediatric Infectious Disease Journal·Jorge E Tolosa
May 14, 2009·BMC Pregnancy and Childbirth·Esme V MenezesZulfiqar A Bhutta
May 8, 2007·Emerging Infectious Diseases·Katherine J GrayStephen M Graham
Dec 19, 2012·Journal of Microbiological Methods·Michele J AndersonMarnie L Peterson
May 3, 2013·American Journal of Infection Control·Charles E EdmistonBrian L Lewis
Apr 3, 2007·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·E M McClureAbdelkrim Smine
Dec 17, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·V D Tsu, P S Coffey
Mar 6, 2007·Best Practice & Research. Clinical Obstetrics & Gynaecology·Paul T Heath, Anne Schuchat
Aug 28, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·G C Di RenzoN El Helali
Jul 26, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Kristin M KnightJ Christopher Glantz
Dec 22, 2009·American Journal of Obstetrics and Gynecology·Ora I SchwopeLarry Rand
Dec 7, 2007·American Journal of Obstetrics and Gynecology·Anna R McNanleyDavid Vicino
Sep 2, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Magdy R AhmedFarzana R Arain
Mar 6, 2015·The Cochrane Database of Systematic Reviews·Anju SinhaNewton Opiyo
Apr 9, 2010·Current Opinion in Infectious Diseases·Jeroen van DillenJos van Roosmalen
Mar 15, 2019·Obstetrics and Gynecology·Cassandra R DuffyCynthia Gyamfi-Bannerman
Jun 11, 2014·The Cochrane Database of Systematic Reviews·Arne Ohlsson, Vibhuti S Shah
Dec 17, 2014·The Cochrane Database of Systematic Reviews·Arne OhlssonBrenda C Stade

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved