Use of vemurafenib in a patient unable to swallow whole

Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners
Brett JansonShahneen Sandhu

Abstract

The treatment landscape for metastatic melanoma has increased dramatically in the past five years, with the pivotal discovery of activating BRAF mutations in half of all melanomas spurring the development for effective treatments that target mitogen-activated protein kinase (RAS/RAF/MEK/ERK) pathway. Vemurafenib, a selective mutant BRAF Val600 inhibitor, results in striking tumour responses and a survival advantage over conventional chemotherapy. We present here the case of a 38-year-old woman with metastatic BRAFV600E mutant melanoma and a severe tablet phobia, who was found to have been crushing and/or chewing her vemurafenib tablets. In this case, she attained a partial response and significant clinical benefit, albeit temporarily.

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Citations

Sep 4, 2020·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·M Darrigade FleuryEwa Wierbiecka-Hainaut
Mar 4, 2017·Clinical Pharmacokinetics·Weijiang ZhangJoseph F Grippo
Nov 16, 2021·Journal of the National Comprehensive Cancer Network : JNCCN·Kevin O'BrienJuvianee I Estrada-Veras

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