Abstract
We report the efficacy of a very low-calorie diet (VLCD)-based weight reduction program in patients with morbid obesity whose elective surgery had been postponed because of being overweight. The safety of weight loss on the immune system will also be evaluated. Thirty patients (mean age, 50 years; weight, 125 kg; BMI, 44 kg/m2) were treated. The program consisted of a 7-week to 24-week VLCD period, supported by individual sessions with a therapist, and of a refeeding period of 1 month before surgery. Two patients discontinued, and the mean weight loss of the remaining 28 patients was 19.6 kg (15% of initial weight). In 23 patients, weight loss was 10% or more of the initial weight. After weight loss, 15 patients underwent surgery, 4 patients did not need an operation, and the remaining 9 patients were not operated on for various reasons. The numbers of circulating leukocytes, neutrophils, basophils, monocytes, CD3+, CD4+, CD8+, and natural killer cells did not change significantly by the ninth week on VLCD or by the end of the program. However, there was a significant (p < 0.05) decrease in the immunoglobulinM serum concentration during the program. In conclusion, a VLCD program is suitable for preoperative weight reduction in ...Continue Reading
References
Mar 1, 1992·The Journal of Hospital Infection·J V Roberts, T Bates
Dec 15, 1992·The American Journal of Cardiology·D GadaletaS Green
May 1, 1991·The American Journal of Clinical Nutrition·R K Chandra
Sep 1, 1991·Diabetes Care·R R Henry, B Gumbiner
Jul 1, 1991·The American Journal of Clinical Nutrition·C J FieldE B Marliss
Feb 1, 1990·Transplantation·J L HolleyT E Starzl
Jun 1, 1990·The American Journal of the Medical Sciences·R W McMurrayN S Pilkington
Oct 1, 1985·The British Journal of Surgery·T W LennardR M Taylor
Jul 1, 1989·Clinical Immunology and Immunopathology·A L Landay, K A Muirhead
Jul 16, 1988·BMJ : British Medical Journal·J S GarrowT W Meade
Apr 1, 1986·Annals of Internal Medicine·P S PasulkaG L Blackburn
Oct 1, 1970·American Journal of Surgery·V V KakkarM B Clarke
Jan 1, 1980·The Journal of Pediatrics·R J MerrittR M Suskind
Mar 1, 1994·Clinical and Diagnostic Laboratory Immunology·D D StalloneG D Foster
Feb 1, 1995·American Journal of Surgery·L F MartinE O Bixler
Mar 15, 1994·Cytometry·J K Nicholson
Oct 1, 1993·Annals of Internal Medicine·T A Wadden
Feb 1, 1992·Obesity Surgery·I KawamuraK Isono
Citations
Jul 18, 2002·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A MartíJ A Martínez
Jul 18, 2002·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·P Mustajoki, T Pekkarinen
Apr 21, 2011·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Fred BrodyMichael Hill
Nov 3, 2005·International Journal of Behavioral Medicine·Hirohito TsuboiOsamu Fukino
Nov 13, 2009·Nutrition Reviews·Rubhana Raqib, Alejandro Cravioto
Nov 30, 2010·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Nawfal W IstfanR Armour Forse
Apr 17, 2009·Medicina clínica·Daniel A De LuisSoledad Rojo
Mar 11, 2006·Biochemical and Biophysical Research Communications·Jenny PalmingMalin Lönn
Apr 14, 2016·Obesity Surgery·Lynda J RossMuhammed Ashraf Memon
Dec 20, 2002·Obesity Research·Ken Fujioka
Feb 16, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·K HongD Heber
Dec 30, 2014·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Silvia Leite FariaMarina Kiyomi Ito
Dec 15, 2017·Obesity Surgery·Helen M RobertsIain L C Chapple
Apr 18, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C N OchnerF Xavier Pi-Sunyer
Mar 1, 2018·Annals of Surgery·Richard J BarthWilliam B Kinlaw
Jul 11, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Mikiko WatanabeLucio Gnessi
Sep 19, 2019·Obesity Surgery·Jonathan SivakumarMichael W Hii
Aug 16, 2018·Obesity Surgery·A Gils ContrerasJ Salas-Salvadó
Feb 19, 2020·Nutrition & Dietetics : the Journal of the Dietitians Association of Australia·Greta HollisJack Bell
Aug 10, 2006·The American Journal of Clinical Nutrition·Susan L CollesPaul E O'Brien
Oct 6, 2020·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·S B GriffinM A Palmer