Use of Vitamin K Antagonists and Brain Morphological Changes in Older Adults: An Exposed/Unexposed Voxel-Based Morphometric Study

Dementia and Geriatric Cognitive Disorders
Antoine BrangierCédric Annweiler

Abstract

Vitamin K antagonists (VKAs) are commonly used for their role in haemostasis by interfering with the vitamin K cycle. Since vitamin K also participates in brain physiology, this voxel-based morphometric study aimed to determine whether the duration of exposure to VKAs correlated with focal brain volume reduction in older adults. In this exposed/unexposed (1: 2) study nested within the GAIT (Gait and Alzheimer Interactions Tracking) cohort, 18 participants exposed to VKA (mean age 75 ± 5 years; 33.3% female; mean exposure 2,122 ± 1,799 days) and 36 matched participants using no VKA (mean age 75 ± 5 years; 33.3% female) underwent MRI scanning of the brain. Cortical grey and white matter volumes were automatically segmented using statistical parametric mapping. Age, gender, educational level, history of atrial fibrillation, type of MRI, and total intracranial volume were included as covariables. The duration of exposure to VKA correlated inversely across the whole brain with the subvolumes of two clusters in the grey matter (right frontal inferior operculum and right precuneus) and one cluster in the white matter (left middle frontal gyrus). In contrast, the grade of white matter hyperintensities did not differ according to the us...Continue Reading

References

Aug 1, 1987·AJR. American Journal of Roentgenology·F FazekasR A Zimmerman
Jan 1, 1980·The American Journal of Medicine·J G HallK M Wilson
Sep 1, 1994·The British Journal of Nutrition·H H Thijssen, M J Drittij-Reijnders
Feb 1, 1994·Stroke; a Journal of Cerebral Circulation·T A ManolioR N Bryan
Sep 1, 2007·NeuroImage·John Ashburner
Aug 19, 2008·Revue neurologique·O GodefroyD Le Gall
Nov 26, 2008·Journal of the American Dietetic Association·Nancy PresseGuylaine Ferland
Nov 13, 2009·Dementia and Geriatric Cognitive Disorders·Anne-Sophie GilliozUNKNOWN REAL.FR Group
Jan 23, 2010·The Journal of Nutritional Biochemistry·Natalia A CrivelloSarah L Booth
Jul 10, 2010·Methods in Molecular Biology·Shaker A Mousa
Nov 4, 2010·JAMA : the Journal of the American Medical Association·Daniel P Sulmasy, Lois Snyder
Mar 16, 2012·BioFactors·Guylaine Ferland
Apr 21, 2012·Advances in Nutrition·Guylaine Ferland
Sep 19, 2012·Dementia and Geriatric Cognitive Disorders·Francesco CacciatorePasquale Abete
Jul 16, 2013·Neurobiology of Aging·Nancy PresseGuylaine Ferland
Dec 21, 2013·Dementia and Geriatric Cognitive Disorders·Cédric AnnweilerOlivier Beauchet
Aug 26, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Cédric AnnweilerOlivier Beauchet
Oct 21, 2015·Journal of the American Geriatrics Society·Cedric AnnweilerOlivier Beauchet
Nov 19, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Guylaine FerlandPascale Barberger-Gateau
Dec 30, 2015·The American Journal of Medicine·Timothy J Poterucha, Samuel Z Goldhaber
May 24, 2016·European Journal of Pharmacology·Xiaoyu JiangHuan Li

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Citations

Sep 14, 2019·The American Journal of Clinical Nutrition·Angela McCannEibhlís M O'Connor
Apr 6, 2019·Frontiers in Neurology·Ludovico AlisiMarco Fiorelli
Jul 3, 2021·Nutrients·Alexander Popescu, Monica German

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