Use of warfarin in elderly patients with non-valvular atrial fibrillation -- subanalysis of the J-RHYTHM Registry

Circulation Journal : Official Journal of the Japanese Circulation Society
Eitaro KodaniJ-RHYTHM Registry Investigators

Abstract

To clarify the effects of warfarin therapy in very old patients with non-valvular atrial fibrillation (NVAF), a post-hoc analysis was performed using the data of the J-RHYTHM Registry. A consecutive series of AF outpatients was enrolled from 158 institutions. Of 7,937 patients, 7,406 with NVAF (men, 70.8%; 69.8±10.0 years) were followed for 2 years or until an event occurred. Patients were divided into 3 age groups (<70, 70-84, and ≥85 years) and 5 subgroups according to international normalized ratio (INR; <1.6, 1.6-1.99, 2.0-2.59, 2.6-2.99, and ≥3.0). Prevalence of female sex, permanent AF, hypertension, coronary artery disease, heart failure, and history of ischemic stroke/transient ischemic attack was higher in the older groups. In the oldest group, 79.7% of patients received warfarin and their time in therapeutic range, using the Japanese target INR of 1.6-2.6, was 67.1%. Rate of thromboembolic events was lower in the age groups <70 and 70-84 years (P=0.027 and P<0.001, respectively) for patients receiving warfarin compared with those who were not. In the oldest group, the rate of thromboembolism plus major hemorrhage was lower at INR 1.6-2.59. Warfarin could have beneficial effects even in very old NVAF patients if INR is...Continue Reading

References

Aug 1, 1991·Stroke; a Journal of Cerebral Circulation·P A WolfW B Kannel
Jul 6, 1995·The New England Journal of Medicine·S C CannegieterE Briët
Jun 13, 2001·JAMA : the Journal of the American Medical Association·B F GageM J Radford
May 26, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroshi InoueKatsusuke Yano
Oct 16, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroshi FurushoShuichi Kaneko
Sep 5, 2009·Journal of the American College of Cardiology·Daniela PoliDomenico Prisco
Sep 4, 2010·Journal of the American College of Cardiology·Ricarda MarinighDeirdre A Lane
Apr 7, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Hirotsugu AtarashiUNKNOWN J-RHYTHM Registry Investigators
Jul 28, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·UNKNOWN J-RHYTHM Registry Investigators
May 28, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroshi InoueUNKNOWN J-RHYTHM Registry Investigators
Jun 27, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·UNKNOWN JCS Joint Working Group
Jul 1, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Masaharu AkaoUNKNOWN Fushimi AF Registry Investigators
Dec 11, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Eitaro KodaniTakeshi Yamashita

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Citations

Feb 19, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Takeshi YamashitaRobert P Giugliano
Mar 7, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Shinichi Goto, Shinya Goto
Jan 26, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Tomoko S KatoUNKNOWN WARCEF Investigators
Jan 5, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Eitaro KodaniUNKNOWN J-RHYTHM Registry Investigators
Oct 2, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Masahiro Yasaka
Mar 11, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Masahiro Yasaka
Mar 24, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Eitaro KodaniUNKNOWN J-RHYTHM Registry Investigators
Apr 28, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Masaomi GohbaraKazuo Kimura
Dec 17, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Eitaro Kodani
Jan 26, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Hsi-Yu YuYih-Sharng Chen
Jun 24, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Yoshimi NumaoTakeshi Yamashita
Sep 14, 2016·Journal of the American Heart Association·Eitaro KodaniUNKNOWN J‐RHYTHM Registry Investigators
Oct 18, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·Yasuo OkumuraUNKNOWN AF Ablation Frontier Registry
Aug 5, 2020·Expert Opinion on Pharmacotherapy·Tatsuya Maruhashi, Yukihito Higashi
Aug 30, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Akinori OchiYouichi Kobayashi
Oct 23, 2019·Annals of Vascular Diseases·Michihisa UmetsuTakashi Kamei
Feb 19, 2021·European Stroke Journal·Masahito TakagiUNKNOWN for BAT2 Investigators
Mar 21, 2021·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Kirolos BarssoumMohan Rao

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