Usefulness of a blood flow analyzing program 3DSRT to detect occipital hypoperfusion in dementia with Lewy bodies

Progress in Neuro-psychopharmacology & Biological Psychiatry
Masaru TatenoMasatoshi Teraoka

Abstract

In the latest criteria for the clinical diagnosis of dementia with Lewy bodies (DLB), supportive features include generalized low uptake on SPECT/PET perfusion scan with reduced occipital activity. In this study, we investigated the usefulness of a cerebral blood flow (CBF) quantification program '3DSRT' in detecting occipital hypoperfusion in DLB. Twenty two patients with probable DLB, 38 patients with probable Alzheimer's disease (AD) and 16 normal controls underwent brain perfusion SPECT. Compared with AD, DLB patients had a bilateral lower CBF in the posterior cerebral segments. The correlation of clinical symptoms and brain blood perfusion was examined by dividing the subjects into subgroups. DLB patients with Parkinsonism, when compared to non-Parkinsonism subgroup, had a lower CBF throughout the cerebrum with statistical significance in the posterior cerebral segments. The quantitative analysis of brain perfusion SPECT by 3DSRT could be a useful supportive measurement in the diagnosis of DLB.

References

Dec 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·N A LassenO B Paulson
Mar 1, 1997·Dementia and Geriatric Cognitive Disorders·R HowardS Williams
Oct 24, 1998·International Psychogeriatrics·C SheaK Rockwood
Jan 15, 2004·European Journal of Nuclear Medicine and Molecular Imaging·Ryo TakeuchiYoshiharu Yonekura
Oct 21, 2005·Neurology·I G McKeithUNKNOWN Consortium on DLB

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Citations

Jun 21, 2013·NMR in Biomedicine·Yasutaka FushimiKaori Togashi
Aug 14, 2009·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Noriyuki KimuraToshio Okazaki
Jan 18, 2014·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Takumi OkudaTetsuya Tono
Feb 9, 2010·Psychiatry Investigation·Masaru TatenoToshikazu Saito

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