Abstract
Solid organ transplant (SOT) candidates may not be immune against potentially vaccine-preventable diseases because of insufficient immunizations and/or limited vaccine responses. We evaluated the impact on vaccine immunity at transplant of a systematic vaccinology workup at listing that included (1) pneumococcal with and without influenza immunization, (2) serology-based vaccine recommendations against measles, varicella, hepatitis B virus, hepatitis A virus, and tetanus, and (3) the documentation of vaccines and serology tests in a national electronic immunization registry (www.myvaccines.ch). Among 219 SOT candidates assessed between January 2014 and November 2015, 54 patients were transplanted during the study. Between listing and transplant, catch-up immunizations increased the patients' immunity from 70% to 87% (hepatitis A virus, P = .008), from 22% to 41% (hepatitis B virus, P = .008), from 77% to 91% (tetanus, P = .03), and from 78% to 98% (Streptococcus pneumoniae, P = .002). Their immunity at transplant was significantly higher against S. pneumoniae (P = .006) and slightly higher against hepatitis A virus (P = .07), but not against hepatitis B virus, than that of 65 SOT recipients transplanted in 2013. This demonstrat...Continue Reading
References
Jan 1, 1992·The Pediatric Infectious Disease Journal·C J WhiteP J Provost
Nov 1, 1990·The Journal of Infectious Diseases·R T ChenW A Orenstein
Aug 1, 1989·Developmental Medicine and Child Neurology·R H LargoG Duc
Sep 1, 1994·The Journal of Infectious Diseases·M L ClementsW Miller
Jan 7, 1999·The Journal of Infectious Diseases·A D JackH C Whittle
Jul 29, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·M DomínguezJ Nuño
Aug 12, 2000·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·E VilleneuveJ P Villeneuve
Feb 15, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E A BlumbergD M Musher
Mar 10, 2001·Transplantation·M GüntherU Bienzle
Jul 11, 2003·Clinical and Diagnostic Laboratory Immunology·Catherine M WernetteMoon H Nahm
Sep 17, 2005·Journal of the American Medical Directors Association·Barbara H BardenheierDale Bratzler
Mar 15, 2006·Nephron. Clinical Practice·Kai Ming ChowPhilip Kam-Tao Li
Feb 9, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D KumarA McGeer
Sep 25, 2007·Vaccine·Beatriz SerranoConsolación Díez
Dec 21, 2007·The New England Journal of Medicine·Jay A Fishman
Aug 22, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Deepali KumarAtul Humar
May 6, 2009·Pediatric Transplantation·Seyed Mohsen DehghaniSeyed Ali Malek-Hosseini
May 14, 2010·Clinical and Vaccine Immunology : CVI·Stanley A Plotkin
Sep 2, 2010·Pediatrics·UNKNOWN American Academy of Pediatrics. Committee on Infectious Diseases
Nov 19, 2011·Pediatric Transplantation·A G L'HuillierK M Posfay-Barbe
Mar 30, 2012·The Journal of Infectious Diseases·Elizabeth A ClutterbuckAndrew J Pollard
May 1, 2012·Antiviral Therapy·Claire-Anne SiegristUNKNOWN H1N1 study group
Jun 1, 2012·Transplantation·Monika LindemannOliver Witzke
Jul 31, 2012·Transplantation Proceedings·I Gutierrez DomingoG Suárez Artacho
Jul 31, 2012·Transplantation Proceedings·I Gutiérrez DomingoG Suárez Artacho
Oct 3, 2012·PloS One·Selma TobudicHeinz Burgmann
Sep 27, 2013·PloS One·Stefania P BjarnarsonIngileif Jonsdottir
Dec 7, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lorry G Rubin Infectious Diseases Society of America
Jun 17, 2014·Clinical Transplantation·Sula MazimbaSalpy V Pamboukian
May 7, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·I HelanteräH Isoniemi
Sep 2, 2016·BMC Public Health·Li ChenJeanne Catherine Koepsell
Nov 22, 2016·Transplant Immunology·Diana A van KesselGer T Rijkers
Jan 25, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J A Fishman
Mar 28, 2017·Transplant International : Official Journal of the European Society for Organ Transplantation·Jay A FishmanRobert A Wilkinson
Jun 26, 2018·Vaccine·Luciana Gomes Pedro BrandãoPedro Emmanuel Alvarenga Americano do Brasil
Citations
Jul 10, 2019·Transplantation·Astrid GardinerSimone I Strasser
Jun 22, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Omid RezahosseiniSusanne Dam Nielsen
Aug 19, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Elana Kreiger-BensonSapna A Mehta
Aug 17, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Erika May Z PinedaJessica Bollinger
Nov 22, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Ricardo M La HozDavid E Greenberg
Dec 2, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Lykke LarsenIsik Somuncu Johansen
Nov 13, 2020·Journal of the Pediatric Infectious Diseases Society·Serge GrazioliGeraldine Blanchard-Rohner
Mar 28, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Florence RunyoGiovanna Melica
Oct 15, 2019·Clinics and Research in Hepatology and Gastroenterology·Florent ValourOdile Launay
May 24, 2021·Vaccine·G Blanchard-RohnerC-A Siegrist
Jul 31, 2021·Expert Review of Clinical Pharmacology·Samantha ScharringaGer T Rijkers
Aug 11, 2021·The American Journal of Cardiology·Alexander DangWissam I Khalife