Usefulness of a systematic approach at listing for vaccine prevention in solid organ transplant candidates

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Geraldine Blanchard-RohnerClaire-Anne Siegrist

Abstract

Solid organ transplant (SOT) candidates may not be immune against potentially vaccine-preventable diseases because of insufficient immunizations and/or limited vaccine responses. We evaluated the impact on vaccine immunity at transplant of a systematic vaccinology workup at listing that included (1) pneumococcal with and without influenza immunization, (2) serology-based vaccine recommendations against measles, varicella, hepatitis B virus, hepatitis A virus, and tetanus, and (3) the documentation of vaccines and serology tests in a national electronic immunization registry (www.myvaccines.ch). Among 219 SOT candidates assessed between January 2014 and November 2015, 54 patients were transplanted during the study. Between listing and transplant, catch-up immunizations increased the patients' immunity from 70% to 87% (hepatitis A virus, P = .008), from 22% to 41% (hepatitis B virus, P = .008), from 77% to 91% (tetanus, P = .03), and from 78% to 98% (Streptococcus pneumoniae, P = .002). Their immunity at transplant was significantly higher against S. pneumoniae (P = .006) and slightly higher against hepatitis A virus (P = .07), but not against hepatitis B virus, than that of 65 SOT recipients transplanted in 2013. This demonstrat...Continue Reading

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Citations

Jun 22, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Omid RezahosseiniSusanne Dam Nielsen
Aug 19, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Elana Kreiger-BensonSapna A Mehta
Aug 17, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Erika May Z PinedaJessica Bollinger
Nov 22, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Ricardo M La HozDavid E Greenberg
Dec 2, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Lykke LarsenIsik Somuncu Johansen
Nov 13, 2020·Journal of the Pediatric Infectious Diseases Society·Serge GrazioliGeraldine Blanchard-Rohner
Mar 28, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Florence RunyoGiovanna Melica
Oct 15, 2019·Clinics and Research in Hepatology and Gastroenterology·Florent ValourOdile Launay
Jul 31, 2021·Expert Review of Clinical Pharmacology·Samantha ScharringaGer T Rijkers
Aug 11, 2021·The American Journal of Cardiology·Alexander DangWissam I Khalife

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