Usefulness of an echo-contrast agent for assessment of coronary flow velocity and coronary flow velocity reserve in the left anterior descending coronary artery with transthoracic doppler scan echocardiography

American Heart Journal
Hideki OkayamaHiroyuki Kawada

Abstract

This study assessed the feasibility of transthoracic Doppler scan echocardiography (TTDE) combined with echo-contrast agent in measuring coronary flow velocity (CFV) and coronary flow velocity reserve (CFVR) in the left anterior descending artery. In 68 consecutive patients who underwent cardiac angiography, TTDE was recorded before and after induction of a hyperemic condition with intravenous administration of adenosine triphosphate (0.14 mg/kg/min). After CFV values returned to baseline, the same measurements were repeated while an echo-contrast agent was continuously infused. CFVR was assessed as the ratio of hyperemic to basal CFV. The pulsed wave Doppler scan quality was graded from 1 to 3 (TTDE score: 1, no signal detection; 2, poor definition of outline; 3, optimal outline definition). Before enhancement, CFVR could not be measured in 20 patients. Prevalence of delayed stenosis (Thrombolysis In Myocardial Infarction [TIMI] II grade flow) in these patients (30%) was significantly greater than in those whose CFVRs could be measured without enhancement (2%; P <.01). TTDE scores both at baseline and after hyperemia were significantly improved with contrast enhancement (before, 2.8 +/- 0.6; after, 3.0 +/- 0.3; P <.01; before,...Continue Reading

Citations

Dec 19, 2017·Journal of Echocardiography·Alberto CozzarinTomás Francisco Cianciulli
May 27, 2015·Nature Reviews. Cardiology·Jenna DeanC Noel Bairey Merz
Sep 30, 2016·Annals of Medicine·Cesare R SirtoriRebecca Perry
Nov 19, 2003·Cardiovascular Ultrasound·Marek KrzanowskiPawel Petkow Dimitrow
May 6, 2021·Echocardiography·Andreina CarboneUNKNOWN Echocardiography study group of the Italian Society of Cardiology

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