Usefulness of bFGF spray in the treatment of perianal abscess and fistula-in-ano.

Pediatric Surgery International
Masayuki KubotaNaoki Okuyama

Abstract

Basic fibroblast growth factor (bFGF) is a newly identified recombinant agent that promotes wound healing through an augmented neovascularization. This study examined the effect of bFGF in the treatment of perianal abscesses. Nine consecutive males with an average age of 5.1 months (1-9 months) who presented with perianal abscess in the past 2 years were treated with bFGF (Transfermin, Kaken Co., Ltd., Tokyo, Japan). Two or three sprays of bFGF were applied to the perianal abscess two times a day. All nine patients responded well to the bFGF treatment. Pus discharge and local swelling around the fistula subsided within a mean of 7.3 ± 1.9 days (1 SD) after the initiation of treatment. One case showed a mild relapse 7 months after treatment and the other developed a new lesion 1 month after treatment. However, these lesions also similarly disappeared after a second treatment with bFGF without a recurrence in the follow-up examinations at 11 and 10 months, respectively. The remaining seven cases have all done well without any recurrence at a mean follow-up period of 14.1 ± 3.2 months. These results clearly indicate the usefulness of the bFGF spray as a new treatment strategy for the management of perianal abscesses.

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Citations

Jul 26, 2011·Pediatric Surgery International·Cağatay Evrim AfşarlarIsmet Faruk Ozgüner
Aug 14, 2012·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·R LewisT M Hammond
Sep 26, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Mikiya InoueTsugumichi Koshinaga
Nov 1, 2016·Techniques in Coloproctology·S H EmileM Abdelnaby
Jun 18, 2017·Techniques in Coloproctology·Jeremy SugruePhilip J Tozer
Sep 29, 2020·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·Jan-Hendrik Gosemann, Martin Lacher
Feb 18, 2021·The Journal of International Medical Research·Marcin WłodarczykJakub Fichna
Nov 21, 2021·Biotechnology Letters·Daniel P FitzpatrickNoel Gately

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