Usefulness of Bisacodyl Testing on Therapeutic Outcomes in Refractory Constipation

Digestive Diseases and Sciences
Edda BattagliaG Bassotti

Abstract

Although chronically constipated patients usually respond to medical treatment, there is a subgroup with scarce/no response, generally labeled as refractory or intractable. However, whether this lack of response is real or due to ancillary causes (suboptimal dosage, lack of compliance etc.) is unknown. To see whether a pharmacologic test (bisacodyl colonic intraluminal infusion during manometric assessment) may predict the therapeutic outcome. Data of patients undergoing 24/h colonic manometry for severe intractable constipation in whom the bisacodyl test (10 ml of drug dissolved into saline and injected through the more proximal recording port) had been carried out were retrieved and analysed, and correlations with the therapeutic outcome made. Overall, charts from 38 patients (5 men) were available; of these, only 21% displayed naive high-amplitude propagated contractions (average, less than 2/24 h), mostly meal-induced, during the recordings. A bisacodyl response was present in 31.6% patients, with a mean number of events of 1.8 per patient. After bisacodyl testing, 47.3% patients underwent intensive medical treatment, 44.7% surgery (medical failures), and 8% transanal irrigation, a procedure employed to treat refractory pat...Continue Reading

References

Dec 1, 1992·International Journal of Colorectal Disease·M A KammJ E Lennard-Jones
Mar 28, 1992·Lancet·M A KammJ E Lennard-Jones
Feb 1, 1988·Diseases of the Colon and Rectum·J S VarmaA N Smith
Feb 1, 1986·Gastroenterology·P Shouler, M R Keighley
Apr 1, 1985·Digestive Diseases and Sciences·D M Preston, J E Lennard-Jones
Sep 22, 2000·Current Gastroenterology Reports·S A Wofford, G N Verne
Dec 10, 2003·Archives of Surgery·Gabrio BassottiAntonio Morelli
Aug 10, 2004·World Journal of Gastroenterology : WJG·Gabrio BassottiAntonio Morelli
Aug 13, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G Bassotti
Aug 13, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S HervéP Ducrotté
Mar 29, 2006·Journal of Pediatric Surgery·Maartje M van den BergHayat M Mousa
May 9, 2006·Gastroenterology·George F LongstrethRobin C Spiller
Feb 20, 2007·Alimentary Pharmacology & Therapeutics·J F Johanson, J Kralstein
Nov 21, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M CamilleriA Wald
Aug 15, 2009·Alimentary Pharmacology & Therapeutics·N ManabeD D Burton
Oct 1, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P G DinningI J Cook
Nov 5, 2010·World Journal of Gastroenterology : WJG·Philip G DinningS Mark Scott
Oct 4, 2011·Internal and Emergency Medicine·Gabrio Bassotti, Vincenzo Villanacci
Oct 4, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·V GiorgioK J Lindley
Oct 13, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A E Bharucha
Dec 25, 2012·Gastroenterology·Adil E BharuchaG Richard Locke
Feb 7, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S SinghS S C Rao
Feb 20, 2013·Expert Opinion on Drug Metabolism & Toxicology·Gabrio Bassotti
May 29, 2014·World Journal of Gastrointestinal Pharmacology and Therapeutics·Gabrio Bassotti, Corrado Blandizzi
Jun 24, 2014·United European Gastroenterology Journal·Luca NeriUNKNOWN LIRS Study Group
May 13, 2015·Techniques in Coloproctology·G Chiarioni, G Bassotti
Oct 2, 2015·Alimentary Pharmacology & Therapeutics·A DudekulaK Bielefeldt
Nov 18, 2015·Techniques in Coloproctology·P ChristensenA V Emmanuel
Dec 10, 2015·Expert Review of Gastroenterology & Hepatology·Gabrio BassottiMassimo Bellini
Dec 20, 2015·Atherosclerosis·Gabrio Bassotti
May 27, 2016·Journal of Neurogastroenterology and Motility·Jeong Eun ShinUNKNOWN Clinical Management Guideline Group under the Korean Society of Neurogastroenterology and Motility
Jun 11, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P G DinningN J Spencer
Oct 27, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·O BorrelliN Thapar
Jan 16, 2017·BMC Gastroenterology·Massimo BelliniUNKNOWN ChroCoDiTE Study Group, AIGO
Feb 22, 2017·Scientific Reports·Ji-Hong ChenJan D Huizinga
Apr 7, 2018·Nature Reviews. Gastroenterology & Hepatology·Jutta KellerUNKNOWN International Working Group for Disorders of Gastrointestinal Motility and Function

❮ Previous
Next ❯

Citations

Jul 10, 2018·Expert Opinion on Pharmacotherapy·Gabrio BassottiMassimo Bellini
Apr 14, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Paul T HeitmannPhil G Dinning
May 28, 2020·Journal of Pediatric Gastroenterology and Nutrition·Silvana BonillaLeonel Rodriguez
Feb 23, 2019·Expert Review of Gastroenterology & Hepatology·Gabrio BassottiMassimo Bellini
Jun 9, 2018·Digestive Diseases and Sciences·Ji-Hong Chen, Jan D Huizinga
Nov 12, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Gabrio Bassotti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.