Dec 14, 2006

Usefulness of body mass index as a sufficient adiposity measurement for sex hormone concentration associations in postmenopausal women

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
S MahabirP R Taylor

Abstract

Both obesity and sex hormones are known risk factors for postmenopausal breast cancer. Although adiposity and sex hormones have been studied in the past, previous reports in postmenopausal women have not been conducted under carefully controlled dietary conditions. In this study, we investigated the usefulness of body mass index (BMI) as a sufficient adiposity measurement to assess associations with sex hormone levels. This study was conducted as a cross-sectional analysis within the control segment (0 g alcohol group) of a randomized, crossover design, in which 51 postmenopausal women consumed 0 (control), 15 (one drink), and 30 (two drinks) g alcohol (ethanol)/d for 8 weeks each as part of a controlled diet. Dual-energy X-ray absorptiometry scans were administered to the women during the control (0 g alcohol) segment, and a blood sample was drawn at the end of that diet period for hormone analysis. In multivariate analysis (adjusted for age, race, family history of breast cancer, parity, and menarche <12 years), women who were overweight or obese had significantly higher serum concentrations of estradiol, bioavailable estradiol, estrone, and estrone sulfate and lower sex hormone-binding globulin than normal weight women (all ...Continue Reading

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Mentioned in this Paper

Prevalence Studies
Serum Hormone Levels (Lab Test)
Sex Hormone-Binding Globulin
Ethanol
Estrone Measurement
Ethanol Measurement
Dual-Energy X-Ray Absorptiometry
Mucopolysaccharidosis III
Estradiol Measurement
Estrogens, endocrine therapy drugs

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