Usefulness of C-reactive protein and left ventricular function for risk assessment in survivors of acute myocardial infarction

The American Journal of Cardiology
Juan SanchisFrancisco J Chorro

Abstract

The additional prognostic information provided by C-reactive protein (CRP) to parameters of left ventricular function in survivors of acute myocardial infarction (AMI) was investigated in 665 patients (326 with ST elevation and 339 with non-ST elevation). Cox multivariable analysis identified the following predictors of 6-month cardiac death: age (per 5 years hazard ratio [HR] 1.2, 95% confidence interval [CI] 1.1 to 1.4, p = 0.004), Killip class >I at presentation (HR 2.4, 95% CI 1.3 to 4.5, p = 0.0001), a reduced ejection fraction (per 5% HR 1.3, 95% CI 1.2 to 1.4, p = 0.0001), and greater CRP (per 5 mg/L HR 1.02, 95% CI 1.01 to 1.04, p = 0.02); the C-index of the model was 0.77 without and 0.78 with CRP. CRP is associated with mortality in addition to age and parameters of ventricular function (Killip class and ejection fraction) in survivors of AMI, although the relevance of its additive predictive role seems marginal.

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Citations

Dec 21, 2007·Nature Clinical Practice. Cardiovascular Medicine·Sammy ElmariahValentin Fuster
Jan 26, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Toshiro KatayamaKatsusuke Yano
May 7, 2014·Cell Biochemistry and Biophysics·Qing LiYuan Wang
Oct 1, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Toshiro KatayamaKatsusuke Yano
Mar 17, 2020·European Heart Journal·Patrick R LawlerPaul M Ridker
Jul 20, 2021·European Cardiology·Ramón Arroyo-EspligueroPablo Avanzas

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