Usefulness of CA 19-9 for pancreatic cancer screening in patients with new-onset diabetes

Hepatobiliary & Pancreatic Diseases International : HBPD INT
Jung Wan ChoeYoung-Tae Bak

Abstract

Generally, carbohydrate antigen 19-9 (CA 19-9) is not useful for screening pancreatic cancer in the asymptomatic general population. This study aimed to evaluate the utility of CA 19-9 level as a screening indicator of pancreatic cancer in asymptomatic patients with new-onset diabetes. We retrospectively reviewed the medical records of patients who visited our health promotion center for health check-ups without cancer related symptoms from January 2005 to January 2014, and were newly diagnosed with diabetes mellitus (DM) within 2 years before their visit. Of the 5111 asymptomatic patients with new-onset DM (<2 years) selected for analyses, 87 (1.7%) eventually developed pancreatic cancer after the health check-up. In the subgroup of 322 patients with high total bilirubin levels (>1.7 mg/dL) at the screening time, 42 (73.7%) of 57 patients with high CA 19-9 levels (>37 IU/mL) had been diagnosed as pancreatic cancer during follow-up period and 12 (4.5%) of 265 patients with normal CA 19-9 levels had finally developed pancreatic cancer (OR = 16.3). In the subgroup of 4789 patients with normal bilirubin levels, pancreatic cancer had been detected in 20 (3.8%) of 522 patients with high CA 19-9 level, while only 13 (0.3%) in 4267 pa...Continue Reading

Citations

Sep 15, 2018·Current Treatment Options in Gastroenterology·Ayush Sharma, Suresh T Chari
Dec 12, 2019·Annals of Hepato-biliary-pancreatic Surgery·Masahide IkeguchiSeiichi Nakamura
Aug 23, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Guopei LuoXianjun Yu
Jan 14, 2021·World Journal of Gastrointestinal Surgery·Tsinrong LeeVishal G Shelat
Aug 29, 2019·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Limei CuiCuiping Liu

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