Usefulness of carvedilol to abolish myocardial postsystolic shortening in patients with idiopathic dilated cardiomyopathy

The American Journal of Cardiology
Takahide ItoYasushi Kitaura

Abstract

Postsystolic shortening (PSS), a positive myocardial velocity after aortic valve closure as assessed by Doppler tissue imaging, is a common pathologic finding in patients with myocardial disease. Beta-blocker therapy can improve global and regional myocardial function. The aim of the present study was to examine whether the beta-blocker carvedilol might reduce the incidence and magnitude of PSS in patients with idiopathic dilated cardiomyopathy. Before and 2 months after carvedilol therapy, 19 patients (7 men, 12 women; mean age 59 +/- 13 years) underwent conventional echocardiographic assessment and Doppler tissue imaging. Time-velocity curves were constructed at the 12 basal and mid myocardial segments of the left ventricular (LV) walls. PSS was defined if positive myocardial velocity after aortic valve closure was greater than the ejection peak. The number of segments showing PSS was assessed before and after carvedilol therapy. Carvedilol decreased LV end-diastolic dimension (from 66 +/- 5 to 62 +/- 7 mm, p <0.01), increased the LV ejection fraction (from 28 +/- 9% to 36 +/- 8%, p <0.01), and increased early diastolic mitral annular velocity (Ea) (from 5.0 +/- 1.6 to 5.5 +/- 1.7 cm/ms, p <0.01). This was associated with sig...Continue Reading

References

Feb 8, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Stig UrheimOtto A Smiseth
May 2, 2003·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Jong-Min SongJae-Kwan Song
May 2, 2003·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Jens-Uwe VoigtWerner G Daniel
Aug 2, 2006·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Takahide ItoYasushi Kitaura
Feb 20, 2007·Journal of the American College of Cardiology·Yasuhiko TakemotoJunichi Yoshikawa

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