Usefulness of colchicine to reduce perioperative myocardial damage in patients who underwent on-pump coronary artery bypass grafting

The American Journal of Cardiology
Georgios GiannopoulosSpyridon Deftereos

Abstract

The objective of the present study was to test whether a perioperative course of colchicine, in patients who underwent standard coronary artery bypass grafting, would result in reduced postoperative increase of myocardial injury biomarker levels. Patients were prospectively randomized to colchicine or placebo starting 48 hours before scheduled coronary artery bypass grafting and for 8 days thereafter (0.5 mg twice daily). The primary outcome parameter was maximal high-sensitivity troponin T (hsTnT) concentration within 48 hours after surgery. Secondary outcome measures were maximal creatine kinase-myocardial brain fraction (CK-MB) levels and area under the curve (AUC) of hsTnT and CK-MB concentrations; 59 patients were included. Maximal hsTnT was 616 pg/ml (396 to 986) in the colchicine group versus 1,613 pg/ml (732 to 2,587) in controls (p = 0.002). Maximal CK-MB was 44.6 ng/ml (36.6 to 68.8) and 93.0 ng/ml (48.0 to 182.3), respectively (p = 0.002). The median AUC for hsTnT was 40,755 pg h/ml (20,868 to 79,176) in controls versus 20,363 pg h/ml (13,891 to 31,661) in the colchicine group (p = 0.002). AUCs for CK-MB were 2,552 ng h/ml (1,564 to 4,791) in controls and 1,586 ng h/ml (1,159 to 2,073) in the colchicine group (p = 0....Continue Reading

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Citations

Jun 9, 2015·The American Journal of Cardiology·Yen-Ting YehYen-Wen Wu
May 12, 2015·The American Journal of Cardiology·Lovely Chhabra, David H Spodick
May 12, 2015·The American Journal of Cardiology·Georgios Giannopoulos, Spyridon Deftereos
Mar 30, 2017·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Kevin ChenVenu Menon
Aug 26, 2015·Journal of the American Heart Association·Stefan M Nidorf, Subodh Verma
Aug 25, 2020·SN Comprehensive Clinical Medicine·Christodoulos PapadopoulosVassilios P Vassilikos
Aug 5, 2015·Expert Opinion on Drug Metabolism & Toxicology·Armen Yuri GasparyanGeorge D Kitas
Aug 29, 2020·Journal of Cardiovascular Medicine·Alessandro AndreisGaetano Maria De Ferrari
May 2, 2020·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Thomas F Whayne
Mar 12, 2021·Internal and Emergency Medicine·Alessandro AndreisGaetano Maria De Ferrari
Aug 10, 2021·Journal of the American Heart Association·Thomas KoflerMatthias Bossard

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