Usefulness of extended nitric oxide analysis in children with allergic rhinitis.

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
Ga Eun KimMyung Hyun Sohn

Abstract

Evaluation of airway inflammation and dysfunction is important in management of allergic rhinitis (AR) since AR is a risk factor for developing asthma. Theoretical nonlinear modeling of exhaled nitric oxide (NO) has revealed extended flow-independent NO parameters that could explain where or how NO metabolism was altered. We aimed to evaluate the association between extended NO parameters and bronchial hyperresponsiveness (BHR) in children with AR. Exhaled NO was measured in 74 children with AR on the same day they underwent the provocholine challenge test (PCT). Extended NO was measured in three different exhaled flow rates (30, 100, 200 mL/s) and calculated using the Högman-Meriläinen model. We compared the extended NO parameters including bronchial NO (JawNO), airway tissue NO (CawNO), alveolar tissue NO (CaNO), and diffusing capacity of NO (DawNO) between AR with and without BHR groups, and analyzed the correlation between extended NO parameters and the response-dose ratio (RDR) of the PCT. We additionally evaluated 49 respiratory healthy controls. Among the 74 children with AR, nine showed BHR. JawNO increased more in children with AR than the control group. In children with AR, JawNO was higher in the AR with BHR than wit...Continue Reading

References

Jun 22, 2006·Respiratory Research·Andrei MalinovschiMarieann Högman
Dec 1, 2007·Journal of Breath Research·M Högman, P Meriläinen
Sep 3, 2011·American Journal of Respiratory and Critical Care Medicine·Raed A DweikUNKNOWN American Thoracic Society Committee on Interpretation of Exhaled Nitric Oxide Levels (FENO) for Clinical Applications
Oct 12, 2012·International Archives of Allergy and Immunology·Ignazio CirilloGiorgio Ciprandi
Dec 19, 2014·Nature Immunology·Bart N Lambrecht, Hamida Hammad
Dec 24, 2014·Nature Reviews. Immunology·John V Fahy
Aug 20, 2015·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Jung-Won LeeSoo-Jong Hong
Dec 19, 2015·The European Respiratory Journal·Antoine FroidureCharles Pilette
Jun 4, 2016·Journal of Asthma and Allergy·Pedro Giavina-BianchiRosana Câmara Agondi
Jul 9, 2016·Thorax·Stefan KarraschAntonius Schneider
Sep 25, 2016·The Journal of Allergy and Clinical Immunology·Joseph D SpahnStanley J Szefler
Oct 6, 2016·Experimental and Therapeutic Medicine·Zheng ZhuJinping Zheng
Nov 20, 2016·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Carla MastrorilliCarlo Caffarelli
Feb 7, 2017·The Journal of Allergy and Clinical Immunology. in Practice·Parameswaran NairPaul M O'Byrne
Mar 3, 2017·International Archives of Allergy and Immunology·Giorgio CiprandiIgnazio Cirillo
Apr 28, 2017·The European Respiratory Journal·Ildiko HorváthTeunis J Vink
Jun 13, 2017·The Journal of Allergy and Clinical Immunology·Jan L BrożekHolger J Schünemann
Mar 27, 2018·Current Allergy and Asthma Reports·Jaymin B MorjariaRiccardo Polosa
Jun 21, 2018·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Zsófia LázárAndrás Bikov
Jan 2, 2019·Asthma Research and Practice·Angelica Tiotiu
Jun 27, 2019·Journal of Breath Research·Tuomas Karvonen, Lauri Lehtimäki
Oct 16, 2019·American Journal of Respiratory and Critical Care Medicine·Brian L GrahamBruce R Thompson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.