Usefulness of gas chromatographic profiles of plasma total lipids in diagnosis of phytosterolemia

Journal of Chromatography
A KuksisD A Roncari

Abstract

A Cambodian male (aged 5 years and 9 months) presented with subcutaneous and tendon xanthomas in association with hypercholesterolemia. He was erroneously diagnosed as having familial hypercholesterolemia and treated with a low cholesterol diet (+/- cholestyramine) to which he did not respond. A determination of plasma total lipid profile by high-temperature gas chromatography revealed elevated plasma levels of free and esterified plant sterols along with the hypercholesterolemia. Introduction and maintenance of a diet low in cholesterol and plant sterols resulted in significant reduction in the blood concentration of these sterols, which returned to pretreatment level upon discontinuation of the low sterol regimen. The rapid identification and quantitation of the plant sterols by high-temperature gas chromatography provides a sensitive means of distinguishing phytosterolemia, which might be more common than previously suspected, from other forms of dyslipidemia, and for following the course of any treatment.

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Citations

Jan 1, 1992·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·T M Hennessey
Jan 5, 2002·Journal of Chromatography. a·P Volin
Jan 5, 2002·Journal of Chromatography. a·A Kuksis
May 7, 2009·The Journal of Biological Chemistry·Jelske N van der VeenFolkert Kuipers
Mar 27, 2001·Current Opinion in Lipidology·M H LeeS B Patel
Feb 18, 2006·Metabolism: Clinical and Experimental·Ashok K BattaGerald Salen
Dec 29, 1999·Journal of the American College of Nutrition·D J Jenkins, C W Kendall
Sep 15, 1995·Journal of Chromatography. B, Biomedical Applications·E B Hoving

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