Usefulness of Global Longitudinal Strain for Early Identification of Subclinical Left Ventricular Dysfunction in Patients With Active Cancer

The American Journal of Cardiology
Michal Laufer-PerlYaron Arbel

Abstract

Cardiotoxicity from cancer therapy has become a leading cause of morbidity and mortality in cancer survivors. The most commonly used definition is cancer therapeutic related cardiac dysfunction defined as a left ventricular ejection fraction (LVEF) reduction of >10%, to a value below 50%. However, according to the recent American and European Society of Echocardiography, global longitudinal strain (GLS) is the optimal parameter for early detection of subclinical left ventricular dysfunction. The objective of this study was to evaluate the frequency of GLS reduction in patients with active cancer and its correlation to other echocardiographic parameters. Data were collected as part of the International Cardio-Oncology Registry. All patients performed at least 2 echocardiograms including GLS. We evaluated the frequency of GLS reduction (≥10% relative reduction), its correlation to LVEF reduction and whether there are other predicting echocardiographic parameters. In 64 consecutive patients, 12 (19%) had ≥10% GLS relative reduction, of which 75% had no concomitant ejection fraction reduction. There were no significant differences in the baseline cardiac risk factors (hypertension, diabetes, hyperlipidemia, or smoking). Treatment w...Continue Reading

Citations

May 28, 2019·Heart Failure Reviews·Sophie I MavrogeniDimitrios Tousoulis
Jul 11, 2019·Current Treatment Options in Cardiovascular Medicine·James P McDonaldVlad G Zaha
Jun 20, 2019·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Michal Laufer-PerlZach Rozenbaum
Jan 30, 2020·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Mohamed Y ElwazirPanithaya Chareonthaitawee
Jul 12, 2019·Journal of Cachexia, Sarcopenia and Muscle·Seyyed Mohammad Reza Kazemi-BajestaniVickie E Baracos
Feb 14, 2021·International Journal of Cardiology·Michal Laufer-PerlLivia Kapusta
Apr 20, 2021·Frontiers in Cardiovascular Medicine·Igor L Gomes-SantosCarlos E Negrão
Jan 8, 2022·American Journal of Therapeutics·Denisa-Corina CiuculeteGheorghe-Andrei Dan

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