Usefulness of hemodynamic changes during adenosine infusion in predicting the diagnostic accuracy of adenosine technetium-99m sestamibi single-photon emission computed tomography (SPECT)

The American Journal of Cardiology
A M AmanullahJ D Friedman

Abstract

Whether adenosine myocardial perfusion single-photon emission computed tomography (SPECT) remains accurate for detecting coronary artery disease (CAD) in the absence of peripheral hemodynamic changes is unknown. To assess the hemodynamic correlates of perfusion defects, we studied 222 consecutive patients (age 71 +/- 11 years) without prior myocardial infarction or revascularization who underwent adenosine technetium (Tc)-99m sestamibi myocardial perfusion SPECT and cardiac catheterization within 6 months of adenosine study. The SPECT protocol used separate acquisition of rest thallium-201 and adenosine Tc-99m sestamibi, which was semiquantitatively analyzed in 20 segments with a visual 5-point scoring system (0 = normal, 4 = absent uptake). The overall sensitivity, specificity, and predictive accuracy of adenosine Tc-99m sestamibi SPECT for detecting significant CAD were 93% (159 of 171), 73% (37 of 51), and 88% (196 of 222), respectively. The study population was grouped into 6 categories as a function of peripheral hemodynamic changes: (1) increase in heart rate by < or = 10 beats/min (n = 135); (2) increase in heart rate by > 10 beats/min (n = 87); (3) decrease in systolic blood pressure by < or = 10 mm Hg (n = 108); (4) de...Continue Reading

References

May 1, 1991·Circulation·I BiaggioniD Robertson
Nov 1, 1990·Circulation·R F WilsonD D Laxson
Feb 1, 1983·Journal of the American College of Cardiology·G A DiamondH J Swan

❮ Previous
Next ❯

Citations

Apr 8, 2015·The International Journal of Cardiovascular Imaging·Takeshi TomiyamaWataru Shimizu
Jan 13, 2005·Seminars in Nuclear Medicine·Rory Hachamovitch, Daniel S Berman
Nov 28, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Naoya MatsumotoSatoshi Saito
Mar 1, 2008·Experimental Lung Research·Harald GroebenWayne Mitzner
Sep 19, 2008·Journal of Cardiovascular Medicine·Mario PetrettaAlberto Cuocolo
Feb 6, 2017·The International Journal of Cardiovascular Imaging·Arash GholoobiVahid Reza Dabbagh Kakhki
Apr 28, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Athanasios KatsikisMaria Koutelou
Jan 8, 2021·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Dimitri PatrikiRonny R Buechel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.