Usefulness of hemoglobin A1c and glycated albumin measurements for insulinoma screening: an observational case-control study.

BMC Cancer
Keiichi TorimotoMasafumi Koga

Abstract

Insulinoma represents hypoglycemia as a predominant symptom; the autonomic symptoms may be resolved by chronically recurrent hypoglycemia resulting in the persistence of non-specific symptoms alone. Therefore, it has been estimated that there are many patients in whom the disease takes longer to diagnose and has remained undiagnosed. Although some parameters exist for the definitive diagnosis of the disease, there are currently no indices for early screening. Indices of glycemic control, hemoglobin A1c (HbA1c), and glycated albumin (GA) may be useful for the screening of patients with insulinoma having chronic hypoglycemia because the values become low in such a condition. Because there are no articles that have reported the point, we examine the effective cutoff values of HbA1c and GA for the diagnosis of insulinoma in the present study. In a multicenter cross-sectional study, 31 patients with insulinoma were included for comparison with 120 control subjects with normal glucose tolerance based on 75 g oral glucose tolerance tests whose characteristics were matched to the patients. The primary outcomes were optimal cutoff values of HbA1c and GA for the screening of insulinoma. HbA1c was significantly lower in the insulinoma gro...Continue Reading

References

Jan 1, 1975·Virchows Archiv. A, Pathological Anatomy and Histology·L GrimeliusB Stenkvist
Nov 1, 1991·Endocrine Reviews·J E GerichA Mitrakou
Jul 1, 1991·Digestive Diseases and Sciences·W KimuraY Morioka
Sep 22, 2000·The Journal of Clinical Endocrinology and Metabolism·B HirshbergP Gorden
Sep 3, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Takuji KouzumaShigeyuki Imamura
Dec 5, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Masafumi KogaSoji Kasayama
Dec 25, 2007·Annals of Surgery·Mehrdad NikfarjamCarlos Fernández-del Castillo
May 30, 2008·Endocrine-related Cancer·Thorvardur R HalfdanarsonGloria M Petersen
Jan 15, 2009·The Journal of Clinical Endocrinology and Metabolism·Kimberly A PlaczkowskiF John Service
Oct 22, 2009·Nature Reviews. Endocrinology·Catarina CoelhoAshley B Grossman
Jan 21, 2012·Neuroendocrinology·Robert T JensenUNKNOWN Barcelona Consensus Conference participants
Jan 25, 2014·European Journal of Endocrinology·Pedro Iglesias, Juan J Díez
Feb 20, 2012·Journal of Diabetes Investigation·Atsunori KashiwagiUNKNOWN Committee on the Standardization of Diabetes Mellitus‐Related Laboratory Testing of Japan Diabetes Society

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Citations

Nov 2, 2019·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Ryosuke KochiHideaki Shimada
Sep 10, 2020·The American Surgeon·Priscilla Y FujikawaBing Yi
Nov 18, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·Mustapha Zendjabil

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