Usefulness of high-sensitivity troponin I for the monitoring of subclinical acute cellular rejection after cardiac transplantation

Transplantation Proceedings
K T AhnE-S Jeon

Abstract

There are conflicting data about the role of cardiac troponin I (cTnI) as determined by means of conventional methods for the prediction of acute rejection after heart transplantation (HT). The purpose of this study was to evaluate whether cTnI as measured by means of the early prototype high-sensitivity assay (hs-cTnI) can predict acute rejection episode after HT compared with grade of rejection in endomyocardial biopsy (EMB). This was a single-center cross-sectional study evaluating cTnI levels with the use of both hs-cTnI and current less sensitive conventional cTnI (conv-cTnI) assays measured at the time of EMB after HT. We calculated an index ratio of observed cTnI to expected mean cTnI for each individual patient defined as the mean cTnI measurements at EMB 60 days after HT. A total of 252 biopsies from 47 patients were included in this study. In the multivariable mixed model analysis in relation to the presence of acute rejection 60 days after HT, hs-cTnI level was significantly related to the presence of rejection (P = .010). The hs-cTnI ratio index was significantly higher at the time of rejection (median, 1.37; interquartile range [IQR], 1.23-2.88) compared with those without rejection (median, 0.90; IQR, 0.51-1.16; P...Continue Reading

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Citations

Sep 30, 2016·Expert Review of Molecular Diagnostics·Michael NasrMinnie Sarwal
Jul 27, 2017·British Journal of Biomedical Science·S GuoC Wang
Nov 9, 2016·Korean Circulation Journal·Ga Yeon LeeEun-Seok Jeon
Jan 6, 2021·Transplantation Reviews·Yeraz KhachatoorianMartin Cadeiras
Mar 27, 2021·Expert Review of Precision Medicine and Drug Development·Mario C Deng
May 12, 2021·Transplant Immunology·Vittorio PalmieriClaudio Napoli
Aug 1, 2021·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Carlos Ortiz-BautistaJuan F Delgado Jiménez

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