Usefulness of histopathological examination in nontraumatic perforation of small intestine

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Garima MahajanSonal Sharma


Nontraumatic perforation of small intestine (NTPSI) is a fairly common cause of peritonitis in developing world requiring early surgical intervention. Various etiological factors have been proposed for the cause of small bowel perforation. This retrospective study was conceded with an aim to determine the prevalence patterns of the different etiologies of NTPSI. A total of 164 patients were included in the study who had segments of small intestine removed for perforation during emergency procedures. Preoperative definitive diagnoses were not known in these cases. On gross examination, most of the small intestine perforations, n =  110 (67%), were found in the terminal ileum. On microscopy, the most frequent category was that of ulcers of nonspecific etiology, n = 61 (37.2%), which showed general features like inflammatory granulation tissue, serositis, and foreign body giant cell reaction. In cases where a definite opinion could be established, infection was the commonest cause, n = 71 (43.3%), wherein tuberculosis (49, 29.9%) and typhoid (22, 13.4%) constituted the greatest number of cases. There were two cases of lymphoma and one case of metastatic adenocarcinoma involving the small intestine. Thus, histopathological examinat...Continue Reading


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Jan 11, 2014·La Radiologia medica·Marirosa Cristallo LacalamitaGiuseppe Angelelli
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Related Concepts

Intestinal Perforation
Intestines, Small
Retrospective Studies
Age Distribution
Selection of Subjects
Emergency Medical Service
Granuloma, Foreign-Body

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