Abstract
A new microfluidic approach using hybrid magnetoliposomes (h-MLs) containing hydrophobic magnetic nanoparticles (Fe3O4@AuNPs-C12SH) and encapsulated N-acetylcysteine has been developed in this research to determine aminoglycoside antibiotic (AAG) residues in food using o-phthalaldehyde. Four AAGs, kanamycin, streptomycin, gentamicin, and neomycin, have been used as model analytes. The h-MLs have been used for reagent preconcentration and were retained using an external electromagnet device in the reaction/detection zone in a microfluidic system, inserted into the sample chamber of a conventional fluorimeter. The formation of a fluorescent isoindole derivate caused an increase in the luminescence signal, which was proportional to the analyte concentration. The dynamic range of the calibration graph was 0.1-1000 μmol L-1, expressed as AAG concentration, with an 8.7 nmol L-1 limit of detection for kanamycin and a sampling frequency of 8 h-1. The method was applied to determine AAG residues in milk and meat samples with recovery values between 87.2 and 107.4%.
References
Jan 1, 1992·Renal Failure·G J Kaloyanides
May 18, 1999·Methods in Molecular Biology·J R Harris, M Adrian
Mar 17, 2004·Journal of Pharmaceutical and Biomedical Analysis·M L Sánchez-MartínezA Gómez-Hens
Jul 28, 2006·Nature·George M Whitesides
Oct 24, 2006·Current Opinion in Chemical Biology·Douglas B Weibel, George M Whitesides
Oct 9, 2007·Analytica Chimica Acta·Bambang KuswandiWillem Verboom
Jan 2, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Chang-Zhu YuWu-Er Gan
May 28, 2011·Journal of Drug Targeting·Caroline BuonocoreZacharias E Suntres
Apr 19, 2012·Chemical Communications : Chem Comm·Do Hyun KangKeesung Kim
Feb 7, 2013·Toxicology Mechanisms and Methods·Misagh AlipourZacharias E Suntres
Feb 6, 2014·Journal of Agricultural and Food Chemistry·Vanessa Román-PizarroAgustina Gómez-Hens
Sep 30, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Aline Ferreira OuriqueRuy Carlos Ruver Beck
Jan 7, 2015·Biosensors & Bioelectronics·Yali ZhangBang-Ce Ye
Dec 17, 2016·Food Chemistry·Vanessa Román-PizarroAgustina Gómez-Hens
Dec 26, 2016·Biosensors & Bioelectronics·Chengke WangRong Tan
Aug 30, 2017·Biochimica Et Biophysica Acta. Biomembranes·Torsten JohnLisandra L Martin
Mar 30, 2018·Mikrochimica Acta·Kai ZhangJinxuan Cao
Sep 13, 2018·The Analyst·Do Hyun KangHo-Sup Jung
Feb 23, 2020·Mikrochimica Acta·Liyong HeNing Gan
Jul 20, 2020·Electrophoresis·Tiago Augusto DonegattiElisabete Alves Pereira
Aug 2, 2020·Analytica Chimica Acta·Dali WeiKun Zeng
Aug 24, 2020·Biochimica Et Biophysica Acta. Biomembranes·Adree KhondkerMaikel C Rheinstädter
Oct 22, 2020·Mikrochimica Acta·Ángela Écija-ArenasJuan Manuel Fernández-Romero
Nov 11, 2020·Talanta·Ángela Écija-ArenasJuan Manuel Fernández-Romero
Dec 21, 2020·Journal of Chromatography. a·Ángela Écija-ArenasJuan Manuel Fernández-Romero