Usefulness of intramyocardial injection of autologous bone marrow-derived mononuclear cells in patients with severe angina pectoris and stress-induced myocardial ischemia

The American Journal of Cardiology
Saskia L M A BeeresDouwe E Atsma

Abstract

Bone marrow cell transplantation has been proposed as a novel therapeutic option for patients with coronary artery disease. This study investigated whether autologous bone marrow-derived mononuclear cell injection into the ischemic myocardium of patients with severe angina pectoris could safely reduce anginal symptoms, improve myocardial perfusion, and increase left ventricular (LV) function. In a total of 20 patients (63 +/- 10 years old; 16 men) with angina pectoris, myocardial segments with stress-induced ischemia as assessed by gated single-photon emission computed tomography were injected with 30 to 100 million mononuclear cells. Anginal symptoms, Canadian Cardiovascular Society class, and quality of life were assessed at 3 and 6 months of follow-up. At baseline and 3 months of follow-up, an exercise test, gated single-photon emission computed tomography, and magnetic resonance imaging were performed to assess exercise capacity, myocardial perfusion, and LV function. Intramyocardial injection of autologous bone marrow-derived mononuclear cells was safe. The Canadian Cardiovascular Society class improved from 3.5 +/- 0.5 at baseline to 2.4 +/- 0.6 after 3 months (p <0.01) and 2.4 +/- 0.6 after 6 months (p <0.01). The qualit...Continue Reading

References

May 15, 2002·Chest·Allan ZelingerMorton E Tavel
Oct 8, 2003·Circulation·Alida E Borger van der BurgMartin J Schalij
Oct 19, 2004·Journal of the American College of Cardiology·Volker SchächingerAndreas M Zeiher
Apr 12, 2005·The American Journal of Cardiology·Theodorus A M KaandorpAlbert de Roos

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Citations

Sep 9, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Peter J PsaltisMartin Rodriguez-Porcel
Nov 30, 2006·Heart Failure Reviews·Frank M Bengel
Jun 19, 2010·Journal of Cardiovascular Translational Research·Eric Fuh, Todd J Brinton
Jun 1, 2012·Journal of Cardiovascular Translational Research·Niall G Campbell, Ken Suzuki
Jul 30, 2011·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Frank M Bengel
Jun 14, 2013·Journal of Translational Medicine·Thomas E IchimAmit N Patel
Jan 27, 2010·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Carmen Wing-Sze ChanHung-Fat Tse
Nov 21, 2007·Journal of Cardiothoracic Surgery·Hilal Al Sabti
Feb 2, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Yun LuanYi-Biao Wang
Jan 1, 2014·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Kamel SadatFadi G Hage
Jan 8, 2011·Journal of Cardiovascular Translational Research·Jan van RamshorstDouwe E Atsma
Dec 22, 2012·Expert Opinion on Biological Therapy·Céline GiordanoMarc Ruel
Apr 25, 2009·Ageing Research Reviews·Lan SunGuanhua Du
Mar 25, 2009·Cardiology Clinics·Riikka Lautamäki, Frank M Bengel
Oct 1, 2008·International Journal of Cardiology·Giulio PompilioPaolo Biglioli
Mar 25, 2008·Experimental Hematology·Silvia CharwatDietmar Glogar
Jul 29, 2008·Journal of Cellular Biochemistry·T J BartoshRouel S Roque
Jun 19, 2015·Stem Cells·Iman Saramipoor BehbahanRobert Peter Gale
Mar 21, 2007·Journal of the American College of Cardiology·Saskia L M A BeeresJeroen J Bax
Jul 21, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Christian S KuhrRainer Storb
Dec 26, 2007·The American Journal of Cardiology·Jacob M van WerkhovenJeroen J Bax
Jun 15, 2007·Journal of Cardiovascular Pharmacology and Therapeutics·Hung-Fat Tse, Chu-Pak Lau
Feb 1, 2018·International Journal of Molecular Sciences·Eswar Kandaswamy, Li Zuo
Jan 13, 2018·World Journal of Stem Cells·Maria DorobantuMiruna Mihaela Micheu
Sep 14, 2007·Scandinavian Journal of Clinical and Laboratory Investigation·M Haack-SorensenJ Kastrup
Oct 19, 2013·Physiological Reviews·Jean-Sébastien SilvestreBernard I Lévy
Jan 17, 2012·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Angel T Chan, M Roselle Abraham
Dec 21, 2018·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·I MannD E Atsma

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