Usefulness of Intratracheal Instillation Studies for Estimating Nanoparticle-Induced Pulmonary Toxicity

International Journal of Molecular Sciences
Yasuo MorimotoKazuhiro Yamamoto

Abstract

Inhalation studies are the gold standard for the estimation of the harmful effects of respirable chemical substances, while there is limited evidence of the harmful effects of chemical substances by intratracheal instillation. We reviewed the effectiveness of intratracheal instillation studies for estimating the hazards of nanoparticles, mainly using papers in which both inhalation and intratracheal instillation studies were performed using the same nanoparticles. Compared to inhalation studies, there is a tendency in intratracheal instillation studies that pulmonary inflammation lasted longer in the lungs. A difference in pulmonary inflammation between high and low toxicity nanoparticles was observed in the intratracheal instillation studies, as in the inhalation studies. Among the endpoints of pulmonary toxicity, the kinetics of neutrophil counts, percentage of neutrophils, and chemokines for neutrophils and macrophages, heme oxygenase-1 (HO-1) in bronchoalveolar lavage fluid (BALF), reflected pulmonary inflammation, suggesting that these markers may be considered the predictive markers of pulmonary toxicity in both types of study. When comparing pulmonary inflammation between intratracheal instillation and inhalation studies...Continue Reading

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Citations

Aug 5, 2016·International Journal of Molecular Sciences·Yasuo MorimotoTakeshi Sasaki
Jun 14, 2017·ACS Applied Materials & Interfaces·Cheng-Chung ChouChung-Yuan Mou
Jul 4, 2018·International Journal of Environmental Research and Public Health·Ching-Chang ChoChih-Sheng Lin
May 22, 2017·Environmental Monitoring and Assessment·Arif M SikderK Maudood Elahi
May 16, 2017·Drug and Chemical Toxicology·Harikiran Lingabathula, Narsimhareddy Yellu
Sep 18, 2018·Journal of Microscopy and Ultrastructure·Reda H ElbakaryMohamed Hassan Ragab
Jan 24, 2019·International Journal of Molecular Sciences·Chengzhu LiaoSie Chin Tjong
May 1, 2021·International Journal of Molecular Sciences·Taisuke TomonagaYasuo Morimoto
Jul 23, 2021·Journal of Toxicologic Pathology·Kazuya TakeuchiSatoshi Furukawa
Apr 26, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Haibing ZhanYingbiao Sun

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Methods Mentioned

BETA
Bronchoalveolar Lavage
MDA

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