Usefulness of MRI-assisted metabolic volumetric parameters provided by simultaneous (18)F-fluorocholine PET/MRI for primary prostate cancer characterization

European Journal of Nuclear Medicine and Molecular Imaging
Yong-Il KimDong Soo Lee

Abstract

The aim of this study was to determine the usefulness of MRI-assisted positron emission tomography (PET) parameters provided by simultaneous (18)F-fluorocholine (FCH) PET/MRI for characterization of primary prostate cancer. Thirty patients with localized prostate cancer (mean age 69.4 ± 6.7 years) confirmed by biopsy were prospectively enrolled for simultaneous PET/MRI imaging. The patients underwent (18)F-FCH PET/MRI 1 week before undergoing total prostatectomy. Multiple parameters of diffusion-weighted MRI [minimum and mean apparent diffusion coefficient (ADCmin and ADCmean)], metabolic PET [maximum and mean standardized uptake value (SUVmax and SUVmean)], and metabolic volumetric PET [metabolic tumor volume (MTV) and uptake volume product (UVP)] were compared with laboratory, pathologic, and immunohistochemical (IHC) features of the prostate cancer specimen. PET parameters were divided into two categories as follows: volume of interest (VOI) of prostate by SUV cutoff 2.5 (SUVmax, SUVmean, MTVSUV, and UVPSUV) and MRI-assisted VOI of prostate cancer (SUVmaxMRI, SUVmeanMRI, MTVMRI, and UVPMRI). The rates of prostate cancer-positive cases identified by MRI alone, (18)F-FCH PET alone, and (18)F-FCH PET/MRI were 83.3, 80.0, and 93...Continue Reading

References

Apr 1, 1986·Journal of Surgical Oncology·D M EuhusF E Johnson
Mar 15, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Anthonius J BreeuwsmaIgle J de Jong
Aug 13, 2005·The American Journal of Surgical Pathology·Jonathan I EpsteinUNKNOWN ISUP Grading Committee
Jan 8, 2008·Oncology·Nobukazu TakahashiKazuya Shizukuishi
Nov 11, 2008·European Journal of Radiology·Gregory RavizziniPeter L Choyke
Apr 1, 2009·Nature Reviews. Clinical Oncology·Hashim U AhmedMark Emberton
Dec 1, 2009·Amino Acids·Hao HongWeibo Cai
Aug 31, 2010·European Journal of Radiology·Chiara FuccioStefano Fanti
Sep 21, 2010·Trends in Molecular Medicine·Alexander W SauterBernd J Pichler
Mar 11, 2011·Urologic Oncology·Bernd Joachim KrauseUwe Treiber
Dec 1, 2011·The Prostate·Susanne LütjePeter F A Mulders
Mar 27, 2012·Theranostics·S SchwarzenböckB J Krause
Jul 25, 2012·AJR. American Journal of Roentgenology·Hossein Jadvar
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Feb 8, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Ralph A BundschuhBernd Joachim Krause
Mar 15, 2013·Clinical Nuclear Medicine·Laura EvangelistaDomenico Rubello
Apr 12, 2013·European Journal of Nuclear Medicine and Molecular Imaging·S M SchwarzenböckB J Krause
May 2, 2013·Annals of Nuclear Medicine·Kazuhiro KitajimaMark A Nathan
Oct 3, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Hossein Jadvar
Oct 3, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Axel WetterJames Nagarajah
Nov 19, 2013·Nuclear Medicine Communications·Finn E von Eyben, Kalevi Kairemo
Apr 3, 2014·Iranian Red Crescent Medical Journal·Mahyar GhafooriMounes Aliyari Ghasabeh
Jun 6, 2014·Nuclear Medicine and Molecular Imaging·Muhammad Kashif RahimDong Soo Lee
Jun 6, 2014·Nuclear Medicine and Molecular Imaging·Soo Jin LeeDong Soo Lee

❮ Previous
Next ❯

Citations

Feb 9, 2016·Diagnostics·Usman BashirGary J Cook
Aug 3, 2018·World Journal of Urology·Jurgen J FuttererUNKNOWN EAU-YAU Prostate Cancer Working Party
Sep 10, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Laura EvangelistaPietro Zucchetta
Feb 14, 2021·Revista española de medicina nuclear e imagen molecular·J R GarciaJ M Santabarbara
May 28, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Thomas A HopeCiprian Catana

❮ Previous
Next ❯

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.