Usefulness of mycophenolate mofetil in Indian patients with C3 glomerulopathy

Clinical Kidney Journal
Joyita BharatiRaja Ramachandran

Abstract

C3 glomerulopathy (C3G) is a heterogeneous disease caused by alternative complement pathway abnormalities without any standardized treatment. An immunosuppressive agent, mycophenolate mofetil (MMF), has been recently shown to be useful in treating C3G, mainly in studies from the west. We report the clinical outcome of 17 Indian C3G patients treated with MMF with or without steroids. The clinical and histology details of the C3G patients treated with MMF for at least 6 months with a follow-up of at least 12 months were retrieved from the medical records of our center. The median serum creatinine and proteinuria at presentation were 0.8 mg/dL and 3.7 g/day, respectively, with the majority (88.2%) presenting as nephrotic syndrome. The mean dose of MMF was 1.65 (±0.56) g/day, and the median duration of MMF therapy was 18 months. Two-thirds (64%) of the patients responded to the treatment, with complete remission in 4 (23%) and partial remission in 7 (41%) (median time: 9 months). Three patients progressed to end-stage renal disease (ESRD) on follow-up. Of the three patients, one (33%) had an initial response in proteinuria to MMF but did not respond after a relapse and subsequently progressed to ESRD and two (67%) other patients we...Continue Reading

References

Mar 11, 1992·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·P TarshishC M Edelmann
Jul 8, 2010·Nature Reviews. Nephrology·Fadi FakhouriMatthew C Pickering
Sep 21, 2010·The Journal of Clinical Investigation·Rubén Martínez-BarricarteSantiago Rodríguez de Córdoba
May 12, 2011·Journal of the Royal Society of Medicine·Daniel P Gale
Dec 16, 2011·The New England Journal of Medicine·Qian ChenPeter F Zipfel
Jan 12, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J A McCaughanA E Courtney
Mar 10, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Andrew S BombackGerald B Appel
Oct 3, 2012·Nature Reviews. Nephrology·Andrew S Bomback, Gerald B Appel
Nov 1, 2013·Kidney International·Matthew C PickeringH Terence Cook
Nov 2, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Nicholas R Medjeral-ThomasH Terence Cook
Dec 9, 2014·Indian Journal of Nephrology·S ThomasG T John
Apr 19, 2015·Diagnostic Pathology·Ganesh Kumar ViswanathanKusum Joshi
May 20, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Karsten HäffnerMartin Pohl
Jul 30, 2015·Kidney International·Cristina RabascoUNKNOWN Spanish Group for the Study of Glomerular Diseases (GLOSEN)
Jun 9, 2016·Renal Failure·Ramachandran RajaVivekanand Jha
Jan 13, 2018·Clinical Journal of the American Society of Nephrology : CJASN·Rupali S AvasareGerald B Appel
Jan 14, 2018·BMC Nephrology·Thomas WelteElke Neumann-Haefelin

❮ Previous
Next ❯

Citations

Dec 11, 2019·Journal of Nephrology·Ashwani KumarRakesh Kumar Vasishta
Sep 24, 2021·Clinical Journal of the American Society of Nephrology : CJASN·Edwin K S WongUNKNOWN MPGN/DDD/C3 Glomerulopathy Rare Disease Group and National Study of MPGN/DDD/C3 Glomerulopathy Investigators

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS
MININEPHPLUS
Excel

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.