Usefulness of myocardial performance index and biochemical markers for early detection of anthracycline-induced cardiotoxicity in adults

Clinical Research in Cardiology : Official Journal of the German Cardiac Society
Fotiní DodosUta C Hoppe

Abstract

Anthracycline therapy is limited by cardiotoxicity. Currently no diagnostic parameter is available allowing ubiquitous and reliable detection of preclinical anthracycline cardiomyopathy and prediction of prognosis. In 100 consecutive patients receiving anthracycline-based chemotherapy serial measurements of left ventricular systolic and diastolic function, Tei index (a Doppler echocardiographic parameter of global ventricular function), cardiac troponin T (cTnT) and NT-probrain natriuretic peptides (BNP) at baseline and during 1-year follow-up were performed. Mean ejection fraction (LVEF) significantly decreased immediately after completion of anthracycline therapy (mean dose 226.1 +/- 8.3 mg/m(2)) und further declined during follow-up (65.9 +/- 0.6% Vs. 61.6 +/- 0.7%; P < 0.001), while mean E/A ratio decreased after 6 months (P = 0.05). No patient presented with cardiac symptoms. The Tei index increased after therapy in the majority of patients (78.8%) compared with pre-therapy values indicating myocardial alteration in more patients than previously recognized. cTnT levels did not exceed the upper limit of the normal range in any patient. Seven patients had low-level elevations of cTnT. Only one of these patients developed a c...Continue Reading

References

Sep 25, 1991·JAMA : the Journal of the American Medical Association·L J SteinherzM L Murphy
Jan 1, 1987·Journal of the American College of Cardiology·B H LeeR T Skeel
Jan 1, 1994·Acta Oncologica·M S EwerM K Thapar
Jul 1, 1996·Annals of Internal Medicine·K ShanJ B Young
Mar 1, 1997·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·C TeiA J Tajik
Aug 15, 1998·American Heart Journal·T SuzukiY Yazaki
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E H HermanV J Ferrans
May 2, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·V B Pai, M C Nahata
Aug 10, 2000·Journal of the American College of Cardiology·D CardinaleC Fiorentini
Apr 5, 2001·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·T SatoG Takada
May 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M T MeinardiW T van der Graaf
Mar 28, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L C M KremerP A Voûte
Jun 22, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D CardinaleC M Cipolla
Jul 13, 2004·The New England Journal of Medicine·Steven E LipshultzStephen E Sallan
Jan 12, 2005·European Journal of Heart Failure·Gedske DaugaardAndreas Kjaer
Mar 19, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S KilickapG Tekuzman
Feb 4, 2006·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Mark BelhamColin Pritchard
Apr 7, 2006·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·M WeberC Hamm
Dec 21, 2006·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·K KurzE Giannitsis
Feb 27, 2007·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Jürgen ScharhagWilfried Kindermann
Apr 25, 2007·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·H J RothR Beneke
Apr 27, 2007·PloS One·Inês RibeiroJuan Carlos Izpisúa Belmonte

❮ Previous
Next ❯

Citations

Feb 22, 2012·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ronny S JijiMichael Salerno
Jan 21, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P J Barrett-LeeM W Verrill
Oct 20, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M AaproU Wedding
Sep 7, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Daniela CardinaleMaria T Sandri
Dec 25, 2012·Future Cardiology·Alessandro Colombo, Daniela Cardinale
Aug 31, 2014·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Juan Carlos PlanaPatrizio Lancellotti
Mar 29, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Laura Cove-SmithHoward R Mellor
Apr 29, 2014·Current Treatment Options in Cardiovascular Medicine·Alessandro ColomboDaniela Cardinale
Apr 14, 2015·Expert Review of Cardiovascular Therapy·Meabh O'HareHoward Lee
May 20, 2015·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·W van BoxtelH W M van Laarhoven
Dec 19, 2015·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Olga H Toro-SalazarKan N Hor
Feb 19, 2014·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Giuseppina MilanoGiulio Pompilio
Apr 2, 2013·Seminars in Oncology·Margot Davis, Ronald M Witteles
Sep 25, 2012·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Lilia OretoTimothy E Paterick
Jan 14, 2011·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Jon M AppelDorte L Nielsen
Aug 24, 2010·Progress in Cardiovascular Diseases·Daniela Cardinale, Maria Teresa Sandri
Oct 31, 2009·Pharmacology & Therapeutics·Emanuel RaschiFabrizio De Ponti
Dec 18, 2015·Heart·Anthony F Yu, Bonnie Ky
Apr 4, 2009·The Lancet Oncology·Renske AltenaJourik A Gietema
Dec 17, 2015·Pediatric Cardiology·Hala AghaMohamed Youssef Abdel Rahman
Feb 29, 2016·Current Treatment Options in Cardiovascular Medicine·Aarti A Patel, Arthur J Labovitz
Aug 18, 2012·Asia-Pacific Journal of Clinical Oncology·Annop KittiwarawutVirote Sriuranpong
Aug 18, 2012·Asia-Pacific Journal of Clinical Oncology·Begül Yağci-KüpeliMünevver Büyükpamukçu
Mar 5, 2011·The American Journal of Cardiology·Heloisa SawayaMarielle Scherrer-Crosbie
Jul 23, 2015·Future Oncology·Michela Salvatici, Maria T Sandri
Sep 5, 2015·Journal of Oncology·Amy A Kirkham, Margot K Davis
Jun 1, 2015·Current Cardiology Reports·Patrick L Stevens, Daniel J Lenihan
Apr 15, 2015·Current Heart Failure Reports·Dhssraj SinghW H Wilson Tang
Aug 26, 2014·Journal of Cardiac Failure·Anthony F YuValentin Fuster
Dec 3, 2014·Clinical Biochemistry·Eric S ChristensonBen H Park
Dec 27, 2016·Critical Reviews in Clinical Laboratory Sciences·Liyun CaoQing H Meng
Jul 1, 2017·Future Cardiology·Robert J Henning, Raymond D Harbison

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

Journal of Cancer Research and Clinical Oncology
F J F BroeyerJ Burggraaf
Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Ruxandra JurcutJens-Uwe Voigt
© 2021 Meta ULC. All rights reserved