Usefulness of non-invasive measurement of cardiac output during sub-maximal exercise to predict outcome in patients with chronic heart failure

The American Journal of Cardiology
Ayumi GodaD M Mancini

Abstract

Peak oxygen consumption (Vo(2)) is a powerful prognostic predictor of survival in patients with chronic heart failure (CHF) because it provides an indirect assessment of a patient's ability to increase cardiac output (CO). However, many patients with CHF who undergo cardiopulmonary exercise testing are unable to perform maximal exercise. New metabolic carts coupled with the inert gas rebreathing technique provide a noninvasive measurement of CO. Whether the noninvasive measurement of CO at a fixed submaximal workload can predict outcome is unknown. This study's population comprised 259 patients (mean age 54 +/- 14 years, mean left ventricular ejection fraction 27 +/- 14%) with CHF who underwent symptom-limited incremental cardiopulmonary exercise testing. Vo(2) and CO were measured at rest, at 25 W, and at peak exercise. Submaximal exercise was defined as <80% peak Vo(2). Among 259 patients, 145 had Vo(2) at 25 W <80% of peak. Vo(2) at 25 W averaged 9.3 +/- 1.8 ml/kg/min. This Vo(2) represented 62 +/- 11% of peak Vo(2), which averaged 15.4 +/- 4.4 ml/kg/min. Prospective follow-up averaged 521 +/- 337 days. In this cohort, there were 15 outcome events (death, urgent heart transplantation, or implantation of a left ventricular as...Continue Reading

References

Jan 11, 1985·The American Journal of Cardiology·K T Weber, J S Janicki
Nov 1, 2005·Journal of the American College of Cardiology·Piergiuseppe AgostoniKarlman Wasserman

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Citations

Oct 14, 2010·Pediatric Cardiology·Gesa WiegandMichael Hofbeck
Nov 2, 2011·Journal of Cardiac Failure·Gaia CattadoriPiergiuseppe Agostoni
Jun 29, 2012·European Journal of Heart Failure·Aaron K F WongChim C Lang
Feb 7, 2013·Journal of Cardiac Failure·Jonathan MyersEuan A Ashley
Jan 22, 2017·Chest·Piergiuseppe AgostoniGaia Cattadori
Apr 26, 2017·Annals of the American Thoracic Society·Carlo Vignati, Gaia Cattadori
Nov 23, 2011·Circulation·Bernard ThibaultUNKNOWN Evaluation of Resynchronization Therapy for Heart Failure (GREATER-EARTH) Investigators
Aug 5, 2020·Expert Review of Cardiovascular Therapy·Ross ArenaAntonio Abbate
Apr 30, 2020·European Journal of Preventive Cardiology·Emanuele AccalaiPiergiuseppe Agostoni
Feb 22, 2021·European Journal of Preventive Cardiology·Emanuele AccalaiPiergiuseppe Agostoni

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