Usefulness of noninvasive methods for the study of bronchial inflammation in the control of patients with asthma

International Archives of Allergy and Immunology
Xavier MuñozEsther Barreiro

Abstract

Bronchial asthma is one of the most prevalent respiratory conditions. Although it is defined as an inflammatory disease, the current guidelines for both diagnosis and follow-up of patients are based only on clinical and lung function parameters. Current research is focused on finding markers that can accurately predict future risk, and on assessing the ability of these markers to guide medical treatment and thus improve prognosis. The use of noninvasive methods to study airway inflammation is gaining increasing support. The study of eosinophils in induced sputum has proved useful for the diagnosis of asthma; however, its clinical implementation is complex. Some studies have shown that the measurement of exhaled nitric oxide (FeNO) may also be useful to establish disease phenotypes and improve control. Others have found that the measurement of pH and certain markers of oxidative stress, cytokines and prostanoids in exhaled breath condensate (EBC) may also be useful as well as the measurement of the temperature of exhaled breath and the analysis of volatile organic compounds (VOCs). In conclusion, since asthma is an inflammatory disease, it seems appropriate to try to control it through the study of airway inflammation using noni...Continue Reading

Citations

Sep 4, 2015·Expert Opinion on Biological Therapy·Amanda R van Buul, Christian Taube
Oct 16, 2016·Environmental Research·Anke HülsTamara Schikowski
Mar 3, 2017·International Archives of Allergy and Immunology·Giorgio CiprandiIgnazio Cirillo
Oct 18, 2016·The Journal of Allergy and Clinical Immunology·Mauro ManiscalcoAndrea Motta
Aug 6, 2017·Journal of Translational Medicine·Chao CaoHuahao Shen
Apr 20, 2016·Journal of Breath Research·N HendelF Pessler
Oct 8, 2020·The World Allergy Organization Journal·Todor A PopovIgnacio J Ansotegui
Mar 25, 2021·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Jocelyne JustMélisande Bourgoin-Heck

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