Usefulness of Novel Immunotherapeutic Strategies for Idiopathic Recurrent Pericarditis

The American Journal of Cardiology
Dor LotanYehuda Adler

Abstract

Idiopathic recurrent pericarditis (IRP) is a debilitating illness which leads to great suffering and multiple hospitalizations. Management of acute pericarditis and subsequent recurrences has evolved significantly as the use of colchicine-based strategies become more prevalent, yet there still remains a subset of patients who remain refractory to colchicine therapy, and these patients require prolonged corticosteroid (CS) therapy for the control of symptoms. Since the 1960s, there have been reports of successful management of these cases with immunosuppressive therapy. Current guidelines support the use of anakinra, intravenous immunoglobulins, and azathioprine for management of IRP, with the goals of both control of symptoms and withdrawal of CS. Recent reports supply evidence for both auto-inflammatory and autoimmune activity in these patients. We herein review the current available reports regarding the evidence regarding the pathophysiology and reported cases and case series of IRP cases managed with immunomodulation therapy.

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Citations

Aug 15, 2018·Expert Review of Cardiovascular Therapy·Alessandro Galluzzo, Massimo Imazio
Jul 20, 2018·Internal and Emergency Medicine·Antonio BrucatoAllan L Klein
Oct 21, 2017·Rheumatology International·Eren Erken, Ertugrul Erken
Apr 9, 2019·Autoimmunity Reviews·Nathan Peiffer-SmadjaPatrice Cacoub
Dec 26, 2019·La Revue de médecine interne·P Cacoub

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