Usefulness of Novel Immunotherapeutic Strategies for Idiopathic Recurrent Pericarditis

The American Journal of Cardiology
Dor LotanYehuda Adler


Idiopathic recurrent pericarditis (IRP) is a debilitating illness which leads to great suffering and multiple hospitalizations. Management of acute pericarditis and subsequent recurrences has evolved significantly as the use of colchicine-based strategies become more prevalent, yet there still remains a subset of patients who remain refractory to colchicine therapy, and these patients require prolonged corticosteroid (CS) therapy for the control of symptoms. Since the 1960s, there have been reports of successful management of these cases with immunosuppressive therapy. Current guidelines support the use of anakinra, intravenous immunoglobulins, and azathioprine for management of IRP, with the goals of both control of symptoms and withdrawal of CS. Recent reports supply evidence for both auto-inflammatory and autoimmune activity in these patients. We herein review the current available reports regarding the evidence regarding the pathophysiology and reported cases and case series of IRP cases managed with immunomodulation therapy.


Jul 1, 1970·American Heart Journal·C H Asplen, H D Levine
Nov 1, 1995·Journal of the American College of Cardiology·R MarcolongoC Agostini
Oct 20, 2006·International Journal of Cardiology·Massimo Imazio, Rita Trinchero
Dec 21, 2006·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·R Dalla PozzaH Netz
Aug 19, 2007·Journal of Cardiovascular Medicine·Massimo ImazioRita Trinchero
Aug 5, 2008·International Journal of Cardiology·Massimo ImazioYehuda Adler
Dec 21, 2010·Clinical Reviews in Allergy & Immunology·Luca CantariniMauro Galeazzi
Feb 8, 2011·International Journal of Cardiology·Fabrizio VianelloRenzo Marcolongo
Feb 9, 2012·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Luca CantariniMassimo Imazio
Aug 27, 2013·The American Journal of Cardiology·Michele MorettiGianfranco Sinagra
Aug 29, 2014·Annals of the Rheumatic Diseases·George LazarosDimitrios Vassilopoulos
Dec 3, 2014·International Journal of Cardiology·Claire MassardierMartin Soubrier
Aug 19, 2015·The American Journal of Cardiology·Sonia JainEric L Matteson
Jan 9, 2016·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Arnon Adler, Michael H Gollob

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