Usefulness of polymerase chain reaction for diagnosing Whipple's disease in rheumatology

PloS One
Marion HerbetteSociété de Rhumatologie de l’Ouest and the network VICTOR HUGO

Abstract

To determine when Tropheryma whipplei polymerase chain reaction (PCR) is appropriate in patients evaluated for rheumatological symptoms. In a retrospective observational study done in rheumatology units of five hospitals, we assessed the clinical and radiological signs that prompted T. whipplei PCR testing between 2010 and 2014, the proportion of patients diagnosed with Whipple's disease, the number of tests performed and the number of diagnoses according to the number of tests, the patterns of Whipple's disease, and the treatments used. Diagnostic ascertainment was based on 1- Presence of at least one suggestive clinical finding; 2- at least one positive PCR test, and 3- a response to antibiotic therapy described by the physician as dramatic, including normalization of C Reactive Protein. At least one PCR test was performed in each of 267 patients. Rheumatic signs were peripheral arthralgia (n = 239, 89%), peripheral arthritis (n = 173, 65%), and inflammatory back pain (n = 85, 32%). Whipple's disease was diagnosed in 13 patients (4.9%). The more frequently positive tests were saliva and stool. In the centres with no diagnoses of Whipple's disease, arthritis was less common and constitutional symptoms more common. The group wi...Continue Reading

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Citations

Apr 5, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Annette MoterManuel Wolters
Apr 5, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alice Tison, Alain Saraux
Nov 19, 2019·Case Reports in Rheumatology·Luca QuartuccioSalvatore De Vita
Dec 7, 2019·Joint, Bone, Spine : Revue Du Rhumatisme·Pauline BrevetOlivier Vittecoq
Jul 2, 2021·Current Rheumatology Reports·Henning Zeidler, Alan P Hudson

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Methods Mentioned

BETA
PCR
biopsy
ESR
biopsies

Software Mentioned

Statistical Package for the Social Sciences ( SPSS

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