Apr 2, 2004

Usefulness of positron emission tomography in diagnosis and treatment follow-up of brain tumors

Neurobiology of Disease
B Schaller

Abstract

Clinical and experimental use of positron emission tomography (PET) is expanding and allows quantitative assessment of brain tumor's pathophysiology and biochemistry. PET therefore provides different biochemical and molecular information about primary brain tumors when compared to histological methods or neuroradiological studies. Common clinical indications for PET contain primary brain tumor diagnosis and identification of the metabolically most active brain tumor reactions (differentiation of viable tumor tissue from necrosis), prediction of treatment response by measurement of tumor perfusion, or ischemia. The interesting key question remains not only whether the magnitude of biochemical alterations demonstrated by PET reveals prognostic value with respect to survival, but also whether it identifies early disease and differentiates benign from malignant lesions. Moreover, an early identification of treatment success or failure by PET could significantly influence patient management by providing more objective decision criteria for evaluation of specific therapeutic strategies. Specially, as PET represents a novel technology for molecular imaging assays of metabolism and signal transduction to gene expression, reporter gene ...Continue Reading

Mentioned in this Paper

Metabolic Process, Cellular
Molecular Imaging
Ischemia
Aspects of Radionuclide Imaging
Tumor Cells, Uncertain Whether Benign or Malignant
SLC38A1 gene
Blood - Brain Barrier Anatomy
Necrosis
Urine
SLC7A8 gene

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