Usefulness of pregnancy-associated plasma protein A in patients with acute coronary syndrome

The American Journal of Cardiology
Kasper K IversenPeer Grande

Abstract

To investigate whether pregnancy-associated plasma protein-A (PAPP-A) is a prognostic marker in patients admitted with high-risk acute coronary syndrome. In patients admitted with high-risk non-ST-segment elevation acute coronary syndrome (NSTE-ACS) and ST-segment elevation myocardial infarction (STEMI), risk stratification is primarily determined by the markers of myocardial necrosis and known demographic risk profiles. However, it has recently been proposed that the presence and extent of vulnerable plaques might influence the prognosis significantly. A marker for the vulnerable plaque could identify patients at high risk who would potentially benefit from intensive treatment and surveillance. Two populations of consecutive patients admitted with high-risk NSTE-ACS (n = 123) and STEMI (n = 314) were evaluated with serial measurements of PAPP-A. The incidence of mortality and nonfatal myocardial infarction was prospectively registered for 2.66 to 3.47 years. In the patients with high-risk NSTE-ACS, PAPP-A was related to the risk of nonfatal myocardial infarction (p = 0.02) and death (p = 0.03). This result was consistent on multivariate analysis of the combination of mortality or nonfatal myocardial infarction (odds ratio 2.65...Continue Reading

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Citations

Mar 20, 2013·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Stephan von HaehlingBoris Bigalke
Jul 30, 2011·Future Cardiology·Jonathan W Waks, Benjamin M Scirica
Dec 25, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yuehua LiRutai Hui
Nov 30, 2010·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Peijing LiuGuanghua Chen
Oct 25, 2014·Biomarkers in Medicine·Camilla H B JespersenKasper Iversen
Apr 18, 2015·Indian Journal of Clinical Biochemistry : IJCB·Nazia ParveenSajitha Krishnan
Apr 1, 2012·Journal of the Saudi Heart Association·Nabeel S Bondagji
Oct 13, 2016·Irish Journal of Medical Science·H Gutiérrez-LeonardN Cárdenas-Rodríguez
Dec 12, 2013·Expert Review of Cardiovascular Therapy·Goran Loncar, Stephan von Haehling
Feb 14, 2015·Expert Review of Molecular Diagnostics·Maria Rubini GimenezChristian Mueller
Nov 17, 2017·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Christos A PapanastasiouEhrin J Armstrong

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