Usefulness of Preoperative 18 F-FDG-PET in Detecting Invasive Intraductal Papillary Neoplasm of the Bile Duct

Anticancer Research
Yoshinobu IkenoShinji Uemoto

Abstract

Preoperative identification of the invasive component remains challenging in intraductal papillary neoplasm of the bile duct (IPNB). We evaluated the ability of preoperative 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) to differentiate between non-invasive IPNB, invasive IPNB, and papillary cholangiocarcinoma (CCA). The maximum standardized uptake values (SUVmax) of 11 patients with IPNB (6 non-invasive and 5 invasive) and 20 with papillary CCA who underwent pre-surgical 18F-FDG-PET were assessed. The SUVmax cut-off that predicts an invasive component was determined using receiver operating characteristic (ROC) curve analysis. The SUVmax in patients with invasive IPNB and papillary CCA were significantly higher than in patients with non-invasive IPNB (p=0.035 and 0.0025, respectively). ROC curve analysis revealed an optimal SUVmax cut-off of 4.5, which had 94.5% accuracy, 76.0% sensitivity, and 100% specificity. Our data suggest that the preoperative 18F-FDG-PET SUVmax can differentiate non-invasive IPNB from invasive IPNB and papillary CCA.

Citations

Aug 18, 2020·Clinical Nuclear Medicine·Zhuolong TuJinfu Tu
Oct 25, 2020·World Journal of Surgical Oncology·Rika FujinoToshio Nakagohri
May 30, 2021·Seminars in Nuclear Medicine·Esra Arslan, Tevfik Fikret Çermik

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