Usefulness of preprocedural serum N-terminal pro-brain natriuretic peptide levels to predict long-term outcome after percutaneous coronary intervention in patients with normal troponin T levels

The American Journal of Cardiology
Nawsad SalehPer Tornvall

Abstract

Our objective was to evaluate the prognostic information of preprocedural serum N-terminus pro-brain natriuretic peptide (NT-pro-BNP) levels to predict the long-term outcome after percutaneous coronary intervention (PCI). A total of 891 consecutive patients with stable or unstable angina pectoris with normal serum troponin T levels (< or =0.03 microg/L) undergoing PCI were investigated. For each patient with a cardiovascular event (death or nonfatal myocardial infarction), 2 event-free patients were used as controls. The procedure was successful in all patients, and follow-up was complete. By the end of the follow-up period (mean 2.6 years), 75 patients had had a cardiovascular event (41 deaths and 34 nonfatal myocardial infarctions). On multivariate analysis, lesion severity, diabetes mellitus, and NT-pro-BNP levels in the highest quartile (>490 mg/L) were identified as independent factors for death or nonfatal myocardial infarction after PCI. In conclusion, preprocedural NT-pro-BNP levels are associated with long-term outcome after PCI. The use of NT-pro-BNP can be of value in risk stratification in patients undergoing PCI.

Citations

Mar 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroshi SakaiMinoru Horie
Jun 17, 2008·The American Journal of the Medical Sciences·Andreas SynetosStamatios Lerakis
Mar 28, 2007·Heart Failure Clinics·Bertil Lindahl, Stefan James
Aug 20, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Marijana SkledarNela Pivac

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