Usefulness of residual plasma fibrinogen after intravenous streptokinase for predicting delay or failure of reperfusion in acute myocardial infarction

The American Journal of Cardiology
A S LewW Ganz

Abstract

The relation between the level of residual plasma fibrinogen and coronary artery reperfusion after 750,000 IU of intravenous (i.v.) streptokinase (SK) was examined in 76 patients with acute myocardial infarction. Both the frequency and rapidity of reperfusion were greater in the 53 patients in whom the residual fibrinogen level was 50 mg/dl or less (low fibrinogen) than in the 23 patients in whom it was more than 50 mg/dl (high fibrinogen). Reperfusion occurred in all 53 patients in the low-fibrinogen group, compared with only 15 patients in the high-fibrinogen group (p less than 0.001). The interval from initiation of SK to clinical signs of reperfusion was 50 +/- 34 minutes in the low-fibrinogen group and 110 +/- 54 minutes in the high-fibrinogen group (p less than 0.001). A high fibrinogen level occurred in 58% of patients who weighed more than 85 kg and in 25% of patients who weighed 85 kg or less (p less than 0.05). No patient who weighed 60 kg or less had a high fibrinogen level. The high-fibrinogen group also had a greater incidence of a high anti-SK antibody titer: 8 of 13 patients (62%) tested, compared with none of the 8 patients tested in the low-fibrinogen group (p less than 0.01). Our data indicate that a high resi...Continue Reading

References

Jan 1, 1979·Progress in Cardiovascular Diseases·N Aoki
Jul 1, 1985·Journal of Cardiovascular Pharmacology·W A SchumacherB R Lucchesi
Apr 15, 1986·The American Journal of Cardiology·M W KrucoffC E Rackley
Jul 1, 1984·Journal of the American College of Cardiology·A S LewW Ganz
Jul 1, 1959·The Journal of Clinical Investigation·N ALKJAERSIGS SHERRY

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Citations

Nov 15, 1996·International Journal of Cardiology·N el GaylaniM B Buchalter
Nov 25, 1989·BMJ : British Medical Journal·P J StaffordD A Chamberlain
May 1, 1989·The American Journal of Cardiology·D C GulbaP R Lichtlen

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