Usefulness of rest and low-dose dobutamine wall motion scores in predicting survival and benefit from revascularization in patients with ischemic cardiomyopathy

The American Journal of Cardiology
Stephen G SawadaHarvey Feigenbaum

Abstract

This study examined the value of wall motion scores at rest and with low- and high-dose dobutamine infusion for prediction of outcome and benefit from revascularization in patients with ischemic cardiomyopathy. Follow-up was obtained in 139 patients with ischemic cardiomyopathy who had echocardiography at rest, and during low- (10 microg/kg/min) and high-dose dobutamine (maximal dose 50 microg/kg/min) infusion. Both rest and low-dose wall motion scores were multivariate predictors of cardiac death, but ischemia and peak dose scores were not predictors. Rest scores risk stratified patients into 3 groups: score (1.00 to 1.99) with 11% cardiac death; score (2.00 to 2.49) with 30% death; and score > or =2.50 with 47% death. One third of patients with rest scores > or =2.50 had improvement in scores to < 2.50 with low-dose dobutamine. Their frequency of cardiac death was reduced to 23% compared with 60% (p = 0.04) in those who remained with low-dose scores > or =2.50. Low-dose scores also identified those who benefited from revascularization. In patients with low-dose scores (1.00 to 1.99), the frequency of cardiac death was marginally lower in revascularized than nonrevascularized patients (10% vs 21%, p = 0.28). In patients with s...Continue Reading

References

Jan 1, 1996·Journal of the American College of Cardiology·M J WilliamsT H Marwick
May 15, 1998·Journal of the American College of Cardiology·N ZafrirS T Dahlberg

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Citations

Aug 29, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Tobias A FuchsPhilipp A Kaufmann
Oct 22, 2013·Current Heart Failure Reports·Saurabh JhaDeborah H Kwon
Apr 10, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Yoichi InabaSteven R Bergmann
Jul 1, 2009·Heart Failure Clinics·Anne S KanderianScott D Flamm
Jun 15, 2007·International Journal of Cardiology·Theodoros XanthosLila Papadimitriou
Jul 2, 2019·Current Opinion in Cardiology·Abhishek Khemka, Stephen G Sawada

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