Usefulness of rheumatoid factor as an immunological and prognostic marker in PSS patients

Clinical Rheumatology
Maria MaślińskaBrygida Kwiatkowska

Abstract

The rheumatoid factor (RF) is present in numerous autoimmune disorders, although its role in many of them remains a subject of research. The study assesses the role of RF as an immunological and prognostic factor in the primary Sjögren's syndrome (pSS). Seventy-five pSS patients (mean age 50.03 ± 15.1), 65 (87%) females, and 10 (13%) males. WBC, CRP, RF, ESR, gammaglobulins, C4, C3 component of complement, cryoglobulins, ANA, anti-SS-A, and anti-SS-B antibodies were determined. The disease activity assessed with ESSDAI. Minor salivary gland biopsy (focus score and immunochemistry) was conducted. Results were analyzed with U Mann-Whitney (continuous variables) tests, correlations between quantitative variables assessed with the Spearman correlation coefficient with statistical significance set at p < 0.05. The approval of the Bioethics Committee was obtained. Two subgroups I-RF(+) (61%) and II-RF(-) (39%) were established, with lower WBC (p = 0.012) and higher ESR (p = 0.016), gammaglobulin concentration (p = 0.007) in group I. Conjunctivitis sicca was more severe in group I. There was positive correlation between RF and lnANA (rho = 0.496), anti-SS-A, anti-SS-B antibodies (rho = 0.448; rho = 0.397 respectively). There was highe...Continue Reading

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Citations

Aug 28, 2020·Clinical and Experimental Immunology·A Y S LeeJ J Wang
Dec 16, 2019·Clinical Rheumatology·Jorge López-MoralesGabriela Hernández-Molina
Apr 14, 2019·Clinical Rheumatology·Elias Toubi, Zahava Vadasz
Jan 27, 2021·Rheumatology International·Maria MaślińskaLakshmanan Suresh
Apr 3, 2020·Praxis·Marco SprecherOliver Distler
Jul 16, 2021·Transplant Immunology·Anna RunströmRobert Bockermann

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