Usefulness of serum cystatin C to determine the dose of vancomycin in critically ill patients

The Journal of Pharmacy and Pharmacology
Akio SuzukiYoshinori Itoh

Abstract

Serum creatinine (Scr) is not a reliable marker of renal function in critically ill patients because of an enhancement of protein catabolism, which makes it difficult to adjust the dosage of renally eliminated drugs such as antibiotics. This study aimed to investigate whether serum cystatin C (Scys-C) could be used as a reliable marker of renal function. We investigated whether Scys-C was a reliable marker of renal function in 56 critically ill patients. Subsequently, the usefulness of Scys-C to determine the initial loading and the maintenance dose of vancomycin was examined in 18 patients. Crea- tinine clearance (Ccr) was assessed from Scr and creatinine in urine collected over 24 h (24-h Ccr). There was a good correlation between 24-h Ccr and 1/Scys-C (r(2) = 0.616), whereas less marked correlation was observed between 24-h Ccr and 1/Scr (r(2) = 0.221). On the other hand, vancomycin concentration was predicted from population pharmacokinetic parameters based on a two-compartment linear model. There were significant correlations between real trough concentrations of vancomycin and the values predicted from Scys-C using various equations (r(2) = 0.416-0.488), while less pronounced relationships were observed between real conce...Continue Reading

References

Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Jul 1, 1990·Kidney International·A S Levey
Jul 1, 1986·Clinical Pharmacokinetics·G R MatzkeD R Guay
Sep 1, 1982·Annals of Internal Medicine·T C SorrellR Munro
Apr 29, 1998·Therapeutic Drug Monitoring·M YasuharaR Hori
Apr 17, 1999·Scandinavian Journal of Clinical and Laboratory Investigation·E J ErlandsenJ H Kristensen
Jun 16, 1999·Clinical Chemistry and Laboratory Medicine : CCLM·E Randers, E J Erlandsen
Jun 30, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A G Bostom, L D Dworkin
Nov 15, 2002·Nutrition·Curtis J WrayPer-Olof Hasselgren
Apr 5, 2003·Kidney International·Manuel FrickerChristoph Schmid
Sep 19, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Frans J HoekRaymond T Krediet
Nov 26, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Peter WiesliChristoph Schmid
Feb 27, 2004·Intensive Care Medicine·Pierre DelanayeGeorges Rorive
Mar 10, 2005·The Medical Clinics of North America·Lesley A Stevens, Andrew S Levey
Mar 19, 2005·Critical Care : the Official Journal of the Critical Care Forum·Patricia VillaPilar Casasnovas
Nov 10, 2005·Critical Care : the Official Journal of the Critical Care Forum·Raymond WulkanArie Berghout
Dec 27, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mitchell H Rosner, W Kline Bolton
Mar 10, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Radovan HojsLudvik Puklavec
Nov 26, 2009·Antimicrobial Agents and Chemotherapy·Akihiro TanakaHiroaki Araki

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Citations

Jun 6, 2013·Biomarkers in Medicine·Timothy J PiantaZoltan H Endre
Feb 7, 2015·British Journal of Clinical Pharmacology·Nguessan Aimé BrouWei Zhao
Aug 5, 2017·Biological & Pharmaceutical Bulletin·Ryota TanakaHiroki Itoh
May 31, 2015·Clinical Chemistry·Noemí Rebollo, Francisco Javier Cepeda-Piorno
Nov 7, 2019·European Journal of Drug Metabolism and Pharmacokinetics·Guo Yu, Guo-Fu Li
Apr 19, 2020·European Journal of Drug Metabolism and Pharmacokinetics·Jie-Jiu LuTao-Tao Liu
Mar 19, 2020·Pharmacy : Journal of Pharmacy, Education and Practice·Hilary R TeafordErin F Barreto
May 7, 2021·Biological & Pharmaceutical Bulletin·Kayoko MatsubaraYasuo Takeda

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