Usefulness of signal-averaged electrocardiography in evaluation of idiopathic-dilated cardiomyopathy in families

The American Journal of Cardiology
G YiW J McKenna

Abstract

Family studies have confirmed that familial dilated cardiomyopathy is common and that a large proportion of relatives have mild left ventricular enlargement and therefore potentially early disease. Previous studies have shown that patients with idiopathic dilated cardiomyopathy have abnormalities of the signal-averaged electrocardiogram (ECG). We assessed the usefulness of analysis of the signal-averaged ECG in the evaluation of familial dilated cardiomyopathy. Signal-averaged electrocardiographic recordings were obtained from 58 patients with idiopathic dilated cardiomyopathy, from 161 of their relatives (35 of whom had left ventricular enlargement), and from 59 healthy subjects. Signal-averaged ECGs were analyzed using both time domain and spectral turbulence analysis techniques. The time domain and spectral turbulence analysis variables were markedly abnormal in patients with idiopathic dilated cardiomyopathy compared with relatives considered normal and healthy controls (p <0.05). Late potentials were more common in patients with idiopathic dilated cardiomyopathy (17%) and in relatives with left ventricular enlargement (20%) than in normal relatives (5%) or healthy controls (5%) (p = 0.003). Spectral turbulence analysis was...Continue Reading

References

Jun 1, 1988·The American Journal of Cardiology·T A BuckinghamH L Kennedy
May 1, 1995·British Heart Journal·P J KeelingW J McKenna
Mar 1, 1994·Computer Methods and Programs in Biomedicine·K HnatkovaM Malik

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Citations

Jul 15, 2006·Orphanet Journal of Rare Diseases·Matthew R G TaylorLuisa Mestroni

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