Usefulness of sonication of cardiovascular implantable electronic devices to enhance microbial detection

The American Journal of Cardiology
Avish NagpalMuhammad R Sohail

Abstract

The cardiovascular implantable electronic device (CIED) infection rate is rising disproportionately to the rate of device implantation. Identification of microorganisms that cause CIED infections is not always achieved using present laboratory techniques. We conducted a prospective study to determine whether device vortexing-sonication followed by culture of the resulting sonicate fluid would enhance microbial detection compared with traditional swab or pocket tissue cultures. Forty-two subjects with noninfected and 35 with infected CIEDs were prospectively enrolled over 12 months. One swab each from the device pocket and device surface, pocket tissue, and the CIED were collected from each patient. Swabs and tissues were cultured using routine methods. The CIED was processed in Ringer's solution using vortexing-sonication and the resultant fluid semiquantitatively cultured. Tissue and swab growth was considered significant when colonies grew on ≥2 quadrants of the culture plate and device was considered significant when ≥20 colonies were isolated from 10 ml of sonicate fluid. In noninfected group, 5% of sonicate fluids yielded significant bacterial growth, compared with 5% of tissue cultures (p = 1.00) and 2% of both pocket and...Continue Reading

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Citations

Jun 2, 2018·Pacing and Clinical Electrophysiology : PACE·Zerelda Esquer GarrigosM Rizwan Sohail
Apr 27, 2018·Journal of Clinical Microbiology·Daniel C DeSimone, M Rizwan Sohail
Apr 19, 2019·Open Forum Infectious Diseases·Zerelda Esquer GarrigosM Rizwan Sohail
Oct 11, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Zerelda Esquer GarrigosM Rizwan Sohail
Apr 9, 2020·Pacing and Clinical Electrophysiology : PACE·Larry M BaddourBradley P Knight
Sep 13, 2019·Annals of Plastic Surgery·Joseph BanuelosBasel Sharaf
Aug 30, 2018·Scientific Reports·Anna GomesBhanu Sinha
Apr 5, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Zerelda Esquer GarrigosRobin Patel
Jun 26, 2021·JACC. Clinical Electrophysiology·Nicholas O PalmeriPeter J Zimetbaum

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